Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS

Human Genetics
Qian WangHongyu Zhao

Abstract

Although some existing epidemiological observations and molecular experiments suggested that brain disorders in the realm of psychiatry may be influenced by immune dysregulation, the degree of genetic overlap between psychiatric disorders and immune disorders has not been well established. We investigated this issue by integrative analysis of genome-wide association studies of 18 complex human traits/diseases (five psychiatric disorders, seven immune disorders, and others) and multiple genome-wide annotation resources (central nervous system genes, immune-related expression-quantitative trait loci (eQTL) and DNase I hypertensive sites from 98 cell lines). We detected pleiotropy in 24 of the 35 psychiatric-immune disorder pairs. The strongest pleiotropy was observed for schizophrenia-rheumatoid arthritis with MHC region included in the analysis (p = 3.9 x 10(-285), and schizophrenia-Crohn's disease with MHC region excluded (p = 1.1 x 10(-36). Significant enrichment (> 1.4 fold) of immune-related eQTL was observed in four psychiatric disorders. Genomic regions responsible for pleiotropy between psychiatric disorders and immune disorders were detected. The MHC region on chromosome 6 appears to be the most important with other regi...Continue Reading

References

Aug 1, 1991·Medical Hypotheses·R S Smith
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Sep 29, 2000·The American Journal of Psychiatry·P F SullivanK S Kendler
Dec 19, 2003·Nucleic Acids Research·Donna KarolchikW James Kent
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser
Jan 11, 2008·The New England Journal of Medicine·Lauren A WeissUNKNOWN Autism Consortium
Jan 22, 2008·Nature Genetics·UNKNOWN International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)Jennifer A Kelly
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
May 12, 2009·Nature Genetics·Jeffrey C BarrettUNKNOWN Type 1 Diabetes Genetics Consortium
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Aug 15, 2009·PLoS Genetics·Bing-Jian FengDavid E Goldgar
Nov 17, 2009·Nature Genetics·Javier Simón-SánchezThomas Gasser
Apr 27, 2010·Nature Genetics·UNKNOWN Tobacco and Genetics Consortium
Aug 6, 2010·The American Journal of Psychiatry·Paul LichtensteinHenrik Anckarsäter
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos
Nov 11, 2010·Genetics·Frank W Stearns
Aug 20, 2011·PLoS Genetics·Chris CotsapasUNKNOWN FOCiS Network of Consortia
Nov 8, 2011·Nucleic Acids Research·Albert PallejàLars Juhl Jensen
Jan 3, 2012·International Journal of Clinical Rheumatology·Mary MargarettenEdward Yelin
Jan 17, 2012·American Journal of Human Genetics·Peter M VisscherJian Yang
Mar 20, 2012·Human Immunology·Silvia IlavskáKatarína Volkovová
Aug 14, 2012·Biological Psychiatry·UNKNOWN Irish Schizophrenia Genomics Consortium and the Wellcome Trust Case Control Consortium 2
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Nov 13, 2012·Trends in Genetics : TIG·Annalise B Paaby, Matthew V Rockman
Feb 20, 2013·BMC Genomics·Alida S D KindtChris S Haley
Mar 5, 2013·Lancet·UNKNOWN Cross-Disorder Group of the Psychiatric Genomics Consortium
Jun 12, 2013·Nature Reviews. Genetics·Nadia SolovieffJordan W Smoller
Aug 7, 2013·Nature Reviews. Genetics·Miles ParkesMatthew A Brown
Aug 13, 2013·Nature Genetics·UNKNOWN Cross-Disorder Group of the Psychiatric Genomics ConsortiumUNKNOWN International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
Nov 12, 2013·Nucleic Acids Research·Minoru KanehisaMao Tanabe

❮ Previous
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Citations

Jun 1, 2016·Frontiers in Neuroscience·Ariel Cariaga-MartinezRaúl Alelú-Paz
May 25, 2016·Neuroscience and Biobehavioral Reviews·Ian P Burges WatsonAdrian J Bradley
Jul 28, 2016·The International Journal of Neuropsychopharmacology·Chung-Feng KaoPo-Hsiu Kuo
Feb 14, 2018·Arthritis Care & Research·Ruth Ann MarrieUNKNOWN Canadian Institutes of Health Research Team in Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Ch
Apr 28, 2018·Schizophrenia Bulletin·Jennie G Pouget
Oct 17, 2018·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Daniel S TyleeStephen J Glatt
Oct 18, 2019·The European Respiratory Journal·Zhaozhong ZhuLiming Liang
Nov 13, 2018·Current Rheumatology Reports·Annaliese TisseverasingheCarol Hitchon
Nov 14, 2019·Journal of Clinical Medicine·Dennis Gibson, Philip S Mehler
Oct 28, 2019·The Journal of Physiology·Matteo M PuscedduMélanie G Gareau
May 29, 2020·Journal of Child and Adolescent Psychopharmacology·Antonella GaglianoEnzo Grossi
Jul 10, 2018·Inflammatory Bowel Diseases·Charles N BernsteinUNKNOWN CIHR Team in Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease
Aug 21, 2018·Case Reports in Medicine·Antonella GaglianoGabriella Di Rosa
Nov 4, 2017·Epidemiology and Psychiatric Sciences·R A MarrieUNKNOWN CIHR Team in Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease
Apr 17, 2018·Genetics and Molecular Biology·Lucas Henriques ViscardiMaria Cátira Bortolini
Nov 24, 2020·Therapeutic Advances in Musculoskeletal Disease·Joel T ParkinsonGolam M Khandaker
Mar 20, 2021·Calcified Tissue International·Ying-Qi LiuHong-Wen Deng
Apr 27, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Micah SilbersteinPhil H Lee
May 19, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Ruth Ann Marrie, Charles N Bernstein
Mar 10, 2019·Schizophrenia Research·Rebecca Birnbaum, Daniel R Weinberger

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