Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments

Nature Communications
Remy ChaitRoy Kishony

Abstract

Antibiotic-sensitive and -resistant bacteria coexist in natural environments with low, if detectable, antibiotic concentrations. Except possibly around localized antibiotic sources, where resistance can provide a strong advantage, bacterial fitness is dominated by stresses unaffected by resistance to the antibiotic. How do such mixed and heterogeneous conditions influence the selective advantage or disadvantage of antibiotic resistance? Here we find that sub-inhibitory levels of tetracyclines potentiate selection for or against tetracycline resistance around localized sources of almost any toxin or stress. Furthermore, certain stresses generate alternating rings of selection for and against resistance around a localized source of the antibiotic. In these conditions, localized antibiotic sources, even at high strengths, can actually produce a net selection against resistance to the antibiotic. Our results show that interactions between the effects of an antibiotic and other stresses in inhomogeneous environments can generate pervasive, complex patterns of selection both for and against antibiotic resistance.

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Citations

Oct 19, 2016·Nature Chemical Biology·Laura K StoneRoy Kishony
Sep 27, 2016·Nature Microbiology·Ylaine GerardinRoy Kishony
Dec 15, 2016·Bioorganic & Medicinal Chemistry Letters·Peter J CossarAdam McCluskey
Oct 28, 2019·Science Translational Medicine·Jianli YinHaifeng Ye
Sep 29, 2017·The Journal of Microbiology·David P E CrabtreeSanghoon Kang
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Oct 22, 2016·Annals of the New York Academy of Sciences·Michael R GillingsSasha G Tetu
Nov 17, 2016·Frontiers in Microbiology·Andrew C SingerAlwyn Hart
Jun 21, 2018·Nature Communications·Daniel BojarMartin Fussenegger
Apr 9, 2019·Journal of the Royal Society, Interface·Fan Wu, Cheemeng Tan
Dec 17, 2020·Viruses·Audrey PageFrançois-Loïc Cosset
Feb 23, 2021·Frontiers in Microbiology·Franziska PietschFrank Schreiber
Sep 29, 2018·Current Opinion in Biomedical Engineering·Feilun WuLingchong You

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Methods Mentioned

BETA
Assay
environmental stresses

Software Mentioned

MATLAB

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