Peste Des Petits Ruminants in Benin: Persistence of a Single Virus Genotype in the Country for Over 42 Years

Transboundary and Emerging Diseases
Caroline M AdombiAdama Diallo

Abstract

Peste des petits ruminants (PPR) is a contagious and often fatal disease affecting sheep and goats. Currently, it is endemic in Africa, the Middle and Near East, the Indian subcontinent and China. Understanding the molecular epidemiology and evolution of PPR virus (PPRV) can assist in the control of the transboundary spread of this economically important disease. We isolated PPRV from pathological and swab samples collected 42 years apart (1969 and 2011) in Benin, West Africa, and sequenced the full genome of two isolates (Benin/B1/1969 and Benin/10/2011). Phylogenetic analysis showed that all of the characterized isolates clustered within viral lineage II and that the 2011 isolates fell into two distinct subgroups. Comparison of the full genome sequences revealed a 95.3% identity at the nucleotide level, while at the protein level, the matrix protein was the most conserved between the two viruses with an identity of 99.7% and only one amino acid substitution over the 42-year sampling period. An analysis of specific amino acid residues of known or putative function did not identify any significant changes between the two viruses. A molecular clock analysis of complete PPRV genomes revealed that the lineage II viruses sampled he...Continue Reading

References

Feb 24, 1996·The Veterinary Record·D D KulkarniB W Narladkar
Dec 18, 2001·Journal of Virological Methods·E Couacy-HymannA Diallo
Feb 19, 2002·Preventive Veterinary Medicine·W P TaylorA K Mukhopadhyay
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Feb 27, 2007·Journal of Comparative Pathology·O KwiatekG Libeau
Sep 17, 2010·The Journal of General Virology·Ashley C BanyardGenevieve Libeau
Jul 19, 2011·Emerging Infectious Diseases·Olivier KwiatekGenevieve Libeau
Jan 21, 2012·Emerging Infectious Diseases·Muhammad MunirKarl Ståhl
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Patrick C Y WooKwok-Yung Yuen
Dec 25, 2012·Emerging Infectious Diseases·Gian Mario CossedduFederica Monaco
Oct 25, 2014·Genome Announcements·William G DundonAdama Diallo
Nov 25, 2014·Emerging Infectious Diseases·Murali MunirajuSatya Parida
May 13, 2015·Transboundary and Emerging Diseases·W G DundonA Diallo

❮ Previous
Next ❯

Citations

Jun 18, 2016·Tropical Animal Health and Production·Hiver BoussiniWilliam G Dundon
May 1, 2019·The Onderstepoort Journal of Veterinary Research·Samuel E MantipSouabou Farougou
Jan 31, 2020·Acta Veterinaria Scandinavica·Edson KinimiGerald Misinzo
Sep 10, 2019·Frontiers in Veterinary Science·Kadidia TounkaraArnaud Bataille
Nov 17, 2020·Frontiers in Veterinary Science·Emeli TorssonOskar Karlsson Lindsjö
Aug 16, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Lingxia LiXiangtao Liu
Mar 18, 2021·Transboundary and Emerging Diseases·Samuel MantipArnaud Bataille

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.