Pesticide behavior in paddy fields and development of azole-resistant Aspergillus fumigatus: Should we be concerned?

Journal de mycologie médicale
A VaeziHamid Badali

Abstract

Tricyclazole as a common fungicide wildly used to control rice blast disease in the Asian country may induce azole resistance in Aspergillus fumigatus isolates. The main reason of the acquired azole resistance is probably environmental exposure through wide fungicide use in agriculture. The present study was conducted with the aim of investigating the current status of the azole-resistant A. fumigatus obtained from the paddy fields with exposure to tricyclazole. A total of 108 soil samples were collected from four different locations of paddy fields in Mazandaran Province, Iran. Pure fungal colonies were initially identified based on the conventional tools, and then reconfirmed by using DNA sequencing of the partial ß-tubulin gene. In addition, the in vitro antifungal susceptibility was determined using the Clinical and Laboratory Standards Institute document (CLSI) M38-A2. The identification of the mutations in the CYP51A gene was accomplished by the implementation of the polymerase chain reaction amplification assay on the selected isolates. Overall, 31 of 108 (28.7%) isolates were identified as A. fumigatus, four (3.7%) of which were recognized as azole-resistant with MICs of itraconazole ≥8μg/ml and voriconazole ≥4μg/ml. On...Continue Reading

Citations

Aug 14, 2019·International Journal of Environmental Health Research·Daniela SimõesRaquel Sabino
Aug 17, 2020·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·María B MedinaSilvia L Resnik
Jul 17, 2020·Frontiers in Cellular and Infection Microbiology·Chukwuemeka Samson AhamefuleWenxia Fang
Oct 7, 2020·Journal of Fungi·Fatemeh AhangarkaniJacques F Meis
Nov 20, 2020·Antibiotics·Chukwuemeka Samson AhamefuleWenxia Fang
Aug 7, 2021·Water Environment Research : a Research Publication of the Water Environment Federation·Otávio von Ameln LovisonAndreza Francisco Martins
Dec 10, 2021·PLoS Pathogens·Rafael W BastosDaniel A Santos

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