Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school children

Pediatrics
P GrandjeanFrodi Debes

Abstract

To examine possible effects on blood pressure, neurological function, and neurobehavioral tests in school-aged children with and without prenatal pesticide exposure in an area where stunting is common. In a community of Northern Ecuador with intensive floriculture and a high female employment rate, we invited 79 children attending the 2 lowest grades of a public school for clinical examinations. In addition to a thorough physical examination, we administered simple reaction time, Santa Ana dexterity test, Stanford-Binet copying, and Wechsler Intelligence Scale for Children-Revised Digit Spans forward. Maternal interview included detailed assessment of occupational history to determine pesticide exposure during pregnancy. Recent and current pesticide exposure was assessed by erythrocyte acetylcholine esterase activity and urinary excretion of organophosphate metabolites. All eligible children participated in the study, but 7 children were excluded from data analysis due to other disease or age >9 years. A total of 31 of the remaining 72 children were classified as stunted based on their height for age. Maternal occupational history revealed that 37 children had been exposed to pesticides during development. After confounder adju...Continue Reading

References

Nov 1, 1987·The American Journal of Clinical Nutrition·M J DibleyF L Trowbridge
Aug 1, 1985·Developmental Medicine and Child Neurology·M Adinolfi
Aug 1, 1995·The Journal of Nutrition·S Grantham-McGregor
Aug 1, 1995·The Journal of Nutrition·B Schürch
Feb 1, 1995·Archives of Disease in Childhood·R MorleyA Lucas
Sep 1, 1995·American Journal of Physical Anthropology·W R LeonardM K McCaston
Nov 1, 1996·Epidemiology·P Factor-LitvakJ Graziano
Jul 1, 1997·Neurotoxicology and Teratology·D C ColeH De Almeida
Nov 5, 1997·American Journal of Industrial Medicine·N FiedlerR Fenske
Dec 11, 1997·Neurotoxicology and Teratology·P GrandjeanP J Jørgensen
Jun 10, 1998·Environmental Health Perspectives·E A GuilletteI E Garcia
Jun 24, 1999·Environmental Health Perspectives·P GrandjeanE C de Oliveira Santos
Dec 14, 1999·Annals of Human Biology·E BénéficeR M Malina
Feb 13, 2001·Environmental Research·J CalderónF Díaz-Barriga
May 15, 2001·Journal of Epidemiology and Community Health·S P WalkerS Grantham-McGregor
Mar 8, 2002·Brain Research. Developmental Brain Research·T A SlotkinF J Seidler
Sep 19, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S M ChangC A Powell
Dec 31, 2003·Environmental Health Perspectives·Perri Zeitz RuckartWendy E Kaye
Feb 3, 2004·Environmental Health Perspectives·Dana B BarrLarry L Needham
Feb 5, 2004·The Journal of Pediatrics·Philippe GrandjeanPál Weihe
Oct 6, 2004·Food and Nutrition Bulletin·Barbara MacdonaldOlivier Receveur
Oct 14, 2004·Nutrition Reviews·Janet BryanJan-Willem van Klinken
Oct 16, 2004·Social Science & Medicine·Carlos Larrea, Ichiro Kawachi
Nov 25, 2004·Pediatric Clinics of North America·Meryl S Cohen
May 1, 2005·Environmental Toxicology and Pharmacology·Stephen Brimijoin

❮ Previous
Next ❯

Citations

Feb 5, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Roshini J Peiris-John, Rajitha Wickremasinghe
Jan 17, 2013·Journal of Exposure Science & Environmental Epidemiology·Alice L CraneDiane S Rohlman
Apr 12, 2012·Journal of Agromedicine·Catherine Karr
Oct 24, 2008·Environmental Health : a Global Access Science Source·Marina Bjørling-PoulsenPhilippe Grandjean
Feb 21, 2009·Environmental Health : a Global Access Science Source·Mathieu Valcke, Michèle Bouchard
Oct 3, 2009·Nihon eiseigaku zasshi. Japanese journal of hygiene·Manabu Hasegawa, Naoya Tsukamoto
Feb 27, 2010·Environmental Health Perspectives·Raul HarariPhilippe Grandjean
Apr 22, 2011·Environmental Health Perspectives·Maryse F BouchardBrenda Eskenazi
Jan 30, 2013·Environmental Health Perspectives·Jose R Suarez-LopezBruce H Alexander
Oct 24, 2013·Environmental Health Perspectives·Youssef Oulhote, Maryse F Bouchard
May 24, 2007·Environmental Health Perspectives·Brenda EskenaziNicholas P Jewell
May 17, 2014·Metabolic Brain Disease·Diane Schertler RohlmanJames R Olson
Mar 12, 2008·Current Opinion in Pediatrics·Lisa G Rosas, Brenda Eskenazi
Jan 21, 2010·Current Opinion in Pediatrics·Philip J Landrigan
Feb 18, 2016·Environmental Health : a Global Access Science Source·Laura Y CabreraJudy Illes
Aug 30, 2008·Critical Reviews in Toxicology·David L EatonPeter S Spencer
Jun 28, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Nirma SamarawickremaJanaka de Silva
Dec 3, 2014·Neurotoxicology and Teratology·Anna L ChoiPhilippe Grandjean
Dec 22, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Diane S RohlmanJames R Olson
Jun 27, 2012·Environment International·María Teresa Muñoz-QuezadaCarlos Concha
Jan 25, 2012·Neurotoxicology·Leslie LondonLorann Stallones
Dec 27, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Tamar LinOra Kofman
Dec 14, 2011·Neurotoxicology·Enrique M OstreaJoel W Ager
Nov 4, 2011·Chemosphere·Reza Dahmardeh BehroozAbbas Esmaili-Sari
Oct 25, 2011·Forensic Science International : Synergy·Matthaios P Kavvalakis, Aristidis M Tsatsakis
Dec 15, 2012·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Jennifer Bevacqua
Aug 12, 2010·Neurotoxicology and Teratology·Jordi JulvezPhilippe Grandjean
Nov 11, 2008·Neurotoxicology·Cécile ChevrierPhilippe Grandjean
Aug 5, 2008·Neurotoxicology and Teratology·Aldina VenerosiGemma Calamandrei
Jun 10, 2008·Neurotoxicology·Diane S RohlmanChristoph van Thriel
Feb 19, 2008·The Science of the Total Environment·Brian L Gulson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.