Pesticide exposure assessment

Toxicology Letters
R I Krieger

Abstract

Unintended, accidental, or unavoidable human exposures may result from pesticide use. Risk Characterization provides registrants, regulators, and the public a means to assess relative risks of pesticide use. Exposure Assessments are less standardized. Potential Dermal Exposure (PDE; mg/kg) is the amount of contact with the potential for dermal absorption (DA). Mixer/loader/applicator data developed using passive dosimetry and skin washing forms a Tier 1 Generic Database. If disqualifying estimates are obtained a more accurate estimate (Tier 2) may be developed from measurements of DA, clothing protection, and PDE under use conditions. Direct estimates of absorbed dose (Tier 3) require metabolic and kinetic data and biological monitoring. Harvesters and other persons who contact treated surfaces need reentry intervals to minimize acute and chronic exposure. Work tasks, dislodgeable foliar residue, and duration of exposure are the foundations for exposure-based, generic estimates of harvester PDE.

References

Dec 31, 1991·Annals of the New York Academy of Sciences·Y Suzuki
Mar 1, 1984·American Industrial Hygiene Association Journal·H N NiggR M Queen

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Citations

Apr 23, 2005·International Archives of Occupational and Environmental Health·Denis AmbroisePascal Wild
Sep 23, 2011·Journal of Occupational and Environmental Hygiene·Timothy J BuckleyMark Boeniger
Apr 20, 2011·Bulletin of Environmental Contamination and Toxicology·Yanhong LiRobert Krieger
Jun 2, 2012·The Science of the Total Environment·Camilo Lesmes-FabianClaudia R Binder
Nov 19, 2015·Journal of Toxicology and Environmental Health. Part a·Gayatri SankaranRobert I Krieger
Mar 28, 2009·Pest Management Science·David NuyttensBart Sonck
Dec 25, 2009·Journal of Applied Toxicology : JAT·Mai A NgoHoward I Maibach
Jul 3, 2013·Pest Management Science·BeiBei GaoDongMei She
Aug 25, 2015·Journal of Toxicology and Environmental Health. Part a·Gayatri SankaranRobert I Krieger
Mar 3, 2006·Regulatory Toxicology and Pharmacology : RTP·Rolf Schulte-HermannFrank M Sullivan
Mar 15, 2000·Regulatory Toxicology and Pharmacology : RTP·J H RossR I Krieger
Feb 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P C JepsonS Kegley
Jan 1, 1999·Journal of Agromedicine·Sara A QuandtRosa M Saavedra
Sep 12, 2003·Environmental Science & Technology·Casey J LeBlancEdward D Schroeder

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