Pesticide-metabolizing enzymes

Toxicology Letters
E HodgsonP E Levi

Abstract

Pesticides are known to function as substrates, inhibitors and inducers of drug-metabolizing enzymes, with the same compound frequently acting in more than one of these roles. Current studies of phase I metabolism of pesticides include cytochrome P450 (P450) and the flavin-containing monooxygenase (FMO), with particular reference to individual isozymes. In mouse liver, the level of FMO1 is gender dependent, FMO3 is gender specific, while FMO5 appears to be gender independent. The isozyme specificity of methylenedioxyphenyl synergists for induction of P450 in mouse liver involves P450s 1A1, 1A2 and 2B10, including a non-Ah receptor-dependent mechanism for 1A2 induction. The substrate specificity of mouse and human P450 and FMO isozymes is discussed.

References

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Citations

Mar 12, 2002·Environmental Science and Pollution Research International·Qasim ChaudhryRoman Marecik
Feb 5, 2004·Ecotoxicology and Environmental Safety·A El-MerhibiT Smeaton
Feb 24, 2016·Frontiers in Physiology·Vijaya Sudhakara Rao KolaMaganti S Madhav
Jun 23, 2015·Ticks and Tick-borne Diseases·Sabine A RichardsChristine Maritz-Olivier
Dec 23, 2014·Environmental Toxicology and Pharmacology·Alessandra PirovanoA Jan Hendriks
Jan 1, 2006·Environmental Toxicology and Pharmacology·B Saradha, P P Mathur
Feb 17, 2006·Mutation Research·Jianhua Zhou, Elizabeth A Shephard
Mar 1, 1996·Environmental Health Perspectives·E Hodgson, P E Levi
Jun 30, 2000·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·M Panemangalore, F N Bebe
Nov 24, 1999·Journal of Biochemical and Molecular Toxicology·P J KorytkoJ G Scott
Feb 9, 2005·Toxicology and Industrial Health·Osman GokalpIrfan Altuntas
Jun 15, 1997·Archives of Biochemistry and Biophysics·J G FallsE Hodgson

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