Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study.

Occupational and Environmental Medicine
Srishti ShresthaDale P Sandler

Abstract

Few studies have evaluated associations between pesticides and hyperthyroidism. We evaluated associations between specific pesticides and incident hyperthyroidism in private pesticide applicators in the Agricultural Health Study. We used Cox proportional hazards models to estimate HRs and 95% CIs for associations between pesticide use at enrolment and hyperthyroidism (n=271) in 35 150 applicators (mostly men), adjusting for potential confounders. Ever use of several pesticides (organophosphate insecticide malathion, fungicide maneb/mancozeb, herbicides dicamba, metolachlor, and atrazine in overall sample and chlorimuron ethyl among those ≤62 years) was associated with reduced hyperthyroidism risk, with HRs ranging from 0.50 (95% CI 0.30 to 0.83) for maneb/mancozeb to 0.77 (95% CI 0.59 to 1.00) for atrazine. Hyperthyroidism risk was lowest among those with higher intensity-weighted lifetime days of using carbofuran and chlorpyrifos (ptrend ≤0.05). Observed associations between pesticides and decreased risk of hyperthyroidism warrant further investigation.

References

Apr 1, 1996·Environmental Health Perspectives·M C AlavanjaA Blair
Jan 12, 2010·American Journal of Epidemiology·Whitney S GoldnerTricia D Levan
Jan 25, 2011·Occupational and Environmental Medicine·Aaron BlairJay H Lubin
Mar 13, 2012·International Journal of Environmental Research and Public Health·Joseph CobleMichael C R Alavanja
Apr 4, 2014·The Journal of Clinical Endocrinology and Metabolism·Allan CarléPeter Laurberg
Apr 4, 2016·Lancet·Simone De LeoLewis E Braverman
Jun 7, 2016·International Journal of Hygiene and Environmental Health·Élida Campos, Carmen Freire
Aug 5, 2017·Occupational and Environmental Medicine·Catherine C LerroMary H Ward
Jun 17, 2018·Environment International·Srishti ShresthaDale P Sandler
Sep 27, 2018·Environmental Health Perspectives·Srishti ShresthaDale P Sandler

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Citations

Dec 27, 2021·The Science of the Total Environment·Carol J Burns, Judy S LaKind

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