Pesticide use and LINE-1 methylation among male private pesticide applicators in the Agricultural Health Study

Environmental Epigenetics
Melannie AlexanderJennifer A Rusiecki

Abstract

Cancer risk may be associated with DNA methylation (DNAm) levels in Long Interspersed Nucleotide Element 1 (LINE-1), a surrogate for global DNAm. Exposure to certain pesticides may increase risk of particular cancers, perhaps mediated in part through global DNAm alterations. To date, human data on pesticide exposure and global DNAm alterations are limited. The goal of this study was to evaluate alterations of LINE-1 DNAm by pesticides in a variety of classes. Data from 596 cancer-free male participants enrolled in the Agricultural Health Study (AHS) were used to examine associations between use of 57 pesticides and LINE-1 DNAm measured via Pyrosequencing in peripheral blood leucocytes. Participants provided information on pesticide use at three contacts between 1993 and 2010. Associations of ever/never pesticide use and lifetime days of application (years of use × days per year) and LINE-1 DNAm level were assessed using linear regression, adjusting for potential confounders (race, age at blood draw, and frequency of drinking alcohol) and other moderately correlated pesticides. After adjustment, ever application of 10 pesticides was positively associated and ever application of eight pesticides was negatively associated with LIN...Continue Reading

References

Jun 22, 1972·The New England Journal of Medicine·S P RothenbergZ Rosenberg
Apr 1, 1996·Environmental Health Perspectives·M C AlavanjaA Blair
Sep 17, 1998·Nature·R Z ChenR Jaenisch
Aug 29, 2002·Journal of Exposure Analysis and Environmental Epidemiology·Jane A HoppinDale P Sandler
May 3, 2003·American Journal of Epidemiology·Michael C R AlavanjaAaron Blair
Oct 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·S P ROTHENBERG
Jan 21, 2004·Nature Reviews. Cancer·Andrew P Feinberg, Benjamin Tycko
Feb 20, 2004·Nucleic Acids Research·Allen S YangJean-Pierre J Issa
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario F FragaManel Esteller
May 13, 2006·Endocrinology·Matthew D Anway, Michael K Skinner
May 19, 2006·Cancer Research·Allen S YangJean-Pierre J Issa
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Mark P PurdueMichael C R Alavanja
Dec 6, 2008·Environmental Health Perspectives·Jennifer A RusieckiEva C Bonefeld-Jorgensen
Jul 21, 2009·Environmental Research·Shannon M LynchMichael C R Alavanja
Feb 16, 2010·Cancer Causes & Control : CCC·Matthew R BonnerMichael C R Alavanja
May 7, 2010·Environmental Health Perspectives·Scott WeichenthalPeter Chan
Jun 2, 2010·Epigenomics·John F Reichard, Alvaro Puga
Apr 1, 2011·Toxicology and Industrial Health·Serdal OgutErdoğan Kucukoner
Jul 22, 2011·International Journal of Environmental Research and Public Health·Wissem MnifBenoit Roig
Sep 20, 2011·International Archives of Occupational and Environmental Health·Sarah E StarksJane A Hoppin
Dec 1, 2011·Epigenomics·Amanda M Hoffman, Paul Cairns
Apr 28, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dana van BemmelLee E Moore
Aug 1, 2012·Environmental and Molecular Mutagenesis·Xiao ZhangLifang Hou
Sep 12, 2012·Environmental Toxicology and Pharmacology·Xiao ZhangLifang Hou
Nov 9, 2012·Cancer Prevention Research·Kevin Brennan, James M Flanagan
Nov 23, 2012·American Journal of Epidemiology·Stella KoutrosMichael C R Alavanja
Jan 17, 2013·CA: a Cancer Journal for Clinicians·Michael C R AlavanjaMatthew R Bonner
Feb 6, 2013·Toxicology·M CollottaV Bollati
Dec 10, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Gabriella AndreottiLee E Moore
Jan 1, 2014·Environmental and Molecular Mutagenesis·Karen HuenNina Holland
Mar 7, 2014·British Journal of Cancer·S M TajuddinUNKNOWN Spanish Bladder Cancer/EPICURO Study investigators
May 27, 2014·Current Environmental Health Reports·Kathryn A Bailey, Rebecca C Fry
Jun 25, 2015·Methods in Molecular Biology·Ali M TabishHyang-Min Byun
Sep 29, 2015·International Journal of Epidemiology·Stella KoutrosLaura E Beane Freeman
Dec 21, 2016·Environmental and Molecular Mutagenesis·Jennifer A RusieckiAndrea Baccarelli

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Citations

Sep 18, 2020·Environmental Science and Pollution Research International·Diana Marcela Paredes-CéspedesYael Yvette Bernal-Hernández
Nov 21, 2020·Environmental and Molecular Mutagenesis·Yanbin ShiLin Ye
Jul 6, 2020·Environment International·Eun Young ParkMin Kyung Lim
Jun 28, 2019·Chemical Research in Toxicology·Diana M Paredes-CéspedesAurora E Rojas-García
Dec 2, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Robin MesnageMichael N Antoniou

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