Pesticides, cognitive functions and dementia: A review

Toxicology Letters
Athina-Maria AloizouEfthimios Dardiotis

Abstract

Pesticides are widely-used chemicals commonly applied in agriculture for the protection of crops from pests. Depending on the class of pesticides, the specific substances may have a specific set of adverse effects on humans, especially in cases of acute poisoning. In past years, evidence regarding sequelae of chronic, low-level exposure has been accumulating. Cognitive impairment and dementia heavily affect a person's quality of life and scientific data has been hinting towards an association between them and antecedent chronic pesticide exposure. Here, we reviewed animal and human studies exploring the association between pesticide exposure, cognition and dementia. Additionally, we present potential mechanisms through which pesticides may act neurotoxically and lead to neurodegeneration. Study designs rarely presented homogeneity and the estimation of the exposure to pesticides has been most frequently performed without measuring the synergic effects and the possible interactions between the toxicants within mixtures, and also overlooking low exposures to environmental toxicants. It is possible that a Real-Life Risk Simulation approach would represent a robust alternative for future studies, so that the safe exposure limits an...Continue Reading

References

Oct 1, 1992·Environmental Research·W DaniellL Rosenstock
Sep 1, 1991·Neurotoxicology and Teratology·M EmaH Kawasaki
Mar 1, 1985·American Journal of Epidemiology·L R FrenchB Christians
Feb 1, 1983·Environmental Health Perspectives·R S MurphyS C Strassman
Jan 17, 1996·Annals of the New York Academy of Sciences·G BissetteT A Slotkin
Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·J LindsayK Rockwood
Mar 1, 1997·Alzheimer Disease and Associated Disorders·R T GunA Mylvaganam
Jul 1, 1997·Neurotoxicology and Teratology·D C ColeH De Almeida
Mar 28, 1998·The European Journal of Neuroscience·S LinnarssonP Ernfors
Apr 7, 2000·Environmental Health Perspectives·K SteenlandC Knott
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·R HébertM F Dubois
Sep 15, 2000·Archives of General Psychiatry·L N YathamT J Ruth
Apr 11, 2001·Lancet·B van Wendel de JoodeD Mergler
Jun 21, 2001·International Journal of Epidemiology·S L TyasP R Montgomery
Sep 15, 2001·Brain Research. Developmental Brain Research·E D LevinT A Slotkin
Mar 8, 2002·Brain Research. Developmental Brain Research·Stephanie J GarciaTheodore A Slotkin
Aug 3, 2002·European Journal of Endocrinology·Lorenz C HofbauerSundeep Khosla
Mar 5, 2003·American Journal of Epidemiology·Isabelle BaldiPatrick Brochard
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·A V TerryM A Prendergast
Mar 28, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rosane Maria SalviDiogo O Souza
Mar 28, 2003·Occupational and Environmental Medicine·T M FarahatW K Anger
Aug 30, 2003·Nature Neuroscience·Mollie K MeffertDavid Baltimore
Nov 5, 2003·Environmental Health Perspectives·Freya KamelDale P Sandler
Nov 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·S M RossoJ C van Swieten
Jun 4, 2004·Environmental Health Perspectives·Julia Green BrodyTheresa Kennedy
Jun 16, 2004·Journal of Neuroscience Research·Jingxin QiuJ Regino Perez-Polo
Jul 21, 2004·Archives of Environmental Health·Mohamed B Abou-Donia
Mar 1, 2005·Neurotoxicology and Teratology·Lola Roldán-TapiaFernando Sánchez-Santed

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Citations

Jun 28, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Vasileios SiokasEfthimios Dardiotis
May 20, 2020·Journal of Molecular Neuroscience : MN·Vasileios SiokasEfthimios Dardiotis
Nov 4, 2020·International Journal of Environmental Research and Public Health·Giorgia AdaniAnnalisa Chiari
Nov 6, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Valentin NăstăsescuManuela Ghica
May 20, 2020·Toxicology Reports·Efthimios DardiotisGeorgios M Hadjigeorgiou
Apr 10, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Aristidis TsatsakisAnca Oana Docea
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Hongyuan ZhaoSridhar Komarneni
May 22, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Aristidis TsatsakisAntonio F Hernández
May 25, 2021·Tremor and Other Hyperkinetic Movements·Daniella Iglesias-HernandezElan D Louis
Jun 6, 2021·Psychopharmacology·Thiago Garcia VargaTatiana Rosado Rosenstock
Aug 28, 2021·International Journal of Environmental Research and Public Health·Federica GiambòLuca Falzone

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