Pestiocandin, a new papulacandin class antibiotic isolated from Pestalotiopsis humus

The Journal of Antibiotics
Katsuyuki SakaiKazuro Shiomi

Abstract

Secondary metabolites of microorganisms have proven to be an excellent source of drugs. We isolated a new antibiotic, named pestiocandin (1), from a culture broth of a filamentous fungus, Pestalotiopsis humus FKI-7473, using a multidrug-sensitive budding yeast, S. cerevisiae 12geneΔ0HSR-iERG6. The structure of 1 was elucidated by various NMR studies. All geometric isomerisms of 1 were shown to be the E-form and two pyranose units of 1 were found to be glucose and galactose types. Compound 1 showed weak growth inhibition against Gram-positive and Gram-negative bacteria, yeasts and a filamentous fungus. It displayed more potent growth inhibition against multidrug-sensitive yeasts than wild-type yeasts.

References

Apr 1, 1985·The Journal of Antibiotics·T Komori, Y Itoh
Jun 1, 1996·The Journal of Antibiotics·E MagomeT Mikawa
Oct 11, 2002·The Journal of Antibiotics·Takao OhyamaMasatoshi Inukai
Apr 15, 2011·Current Opinion in Chemical Biology·Jiyong Hong
Aug 9, 2011·Bioscience, Biotechnology, and Biochemistry·Takumi ChinenTakeo Usui

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Citations

Nov 5, 2020·MBio·Giuseppe Buda De CesareMichael C Lorenz

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Methods Mentioned

BETA
NMR

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