PET-adapted approaches to primary therapy for advanced Hodgkin lymphoma

Therapeutic Advances in Hematology
Noemie Lang, Michael Crump

Abstract

Recent results of randomized phase III studies of FDG-PET-adapted therapy for advanced Hodgkin lymphoma (HL) have clearly demonstrated benefit to alteration of treatment according to interim response, in particular regarding reducing toxicity while maintaining efficacy. However, these studies have differences in design including initial chemotherapy regimen, PET response criteria, patient populations enrolled, and inclusion of radiation, and report different results regarding efficacy and toxicities, which makes cross-trial comparisons difficult. Practitioners are presented with deciding which of these approaches will provide the optimum outcome, balancing toxicity and efficacy, and for which patient with advanced-stage HL. This review summarizes the observations reported from these trials and provides context to help guide physicians and patients in treatment decisions for advanced HL.

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Citations

Dec 29, 2020·Leukemia & Lymphoma·Noemie Lang, John Kuruvilla

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Methods Mentioned

BETA
imaging technique
sperm collection

Clinical Trials Mentioned

NCT02661503
NCT03907488

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