PMID: 2957716Jan 1, 1987Paper

PET analysis of human dopamine receptor subtypes using 11C-SCH 23390 and 11C-raclopride

Psychopharmacology
Lars FardeGöran Sedvall

Abstract

Tracer doses of 11C-SCH 23390 and 11C-raclopride, selective D1-dopamine and D2-dopamine receptor antagonists, respectively, were injected intravenously into three healthy male volunteers and two drug-treated schizophrenic patients. Regional radioactivity in brain and plasma was followed during 1 h by positron emission tomography (PET). After injection of both ligands a high accumulation of radioactivity was observed in the dopamine-rich caudate putamen. Experiments with 11C-SCH 23390, but not 11C-raclopride, showed a conspicuous accumulation of radioactivity also in the neocortex. None of the ligands accumulated in the dopamine-poor cerebellum. Specific binding of 11C-raclopride in the putamen was reduced by more than 80% in schizophrenic patients treated with antipsychotic doses of sulpiride or cis(Z)-flupentixol decanoate. 11C-SCH 23390 binding was slightly reduced in both the cortex and the putamen after treatment with cis(Z)-flupentixol decanoate but not after sulpiride. The results indicate that clinical antipsychotic drug treatment with sulpiride and cis(Z)-flupentixol decanoate causes a substantial blockade of D2-dopamine receptors in the basal ganglia but has only a minor effect on D1-dopamine receptors.

References

Jan 11, 1979·Nature·J W Kebabian, D B Calne
Jul 31, 1985·European Journal of Pharmacology·R RaismanY Agid
Aug 15, 1985·European Journal of Pharmacology·C PimouleS Z Langer
Apr 21, 1986·Life Sciences·P H Andersen, F C Grønvald
Jan 1, 1986·Advances in Experimental Medicine and Biology·G SedvallC Halldin
Oct 1, 1986·Archives of General Psychiatry·G SedvallF A Wiesel
Jan 1, 1986·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·C HalldinG Sedvall
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L FardeG Sedvall
Feb 5, 1985·European Journal of Pharmacology·T M DawsonJ K Wamsley
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J W KebabianP Greengard
Jan 1, 1983·Annual Review of Neuroscience·I CreeseS E Leff
Jul 15, 1983·European Journal of Pharmacology·J Hyttel
Mar 15, 1984·Biochemical Pharmacology·P M Laduron
Oct 30, 1984·European Journal of Pharmacology·D W SchulzR B Mailman
Feb 1, 1981·Journal of Computer Assisted Tomography·M BergströmL Widén

❮ Previous
Next ❯

Citations

Jan 1, 1990·European Journal of Nuclear Medicine·B Mazière, M Mazière
Apr 1, 1995·European Journal of Nuclear Medicine·J T KuikkaP Hakola
Jan 1, 1994·European Archives of Psychiatry and Clinical Neuroscience·G SedvallL Farde
Dec 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Kjell NågrenJuha O Rinne
May 3, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jesper EkelundMarc Laruelle
Aug 2, 1988·Brain Research·J Marcusson, K Eriksson
May 1, 1993·Pharmacology, Biochemistry, and Behavior·R CorbettR W Dunn
Jul 20, 1991·Lancet·D E Casey
Mar 1, 1992·Neurochemistry International·H HallG Sedvall
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Wolfarth, K Ossowska
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·R KaminskiM Davidson
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·F A WieselG Sedvall
Jan 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·M R Lynch
Oct 9, 1989·Neuroscience Letters·J De KeyserG Vauquelin
Jan 1, 1989·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·S RamL D Spicer
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·C HalldinG Sedvall
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·S M MoerleinM J Welch
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·C HalldinG Sedvall
Jun 1, 1992·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·H F BeerP A Schubiger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
C HalldinGöran Sedvall
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
C HalldinGöran Sedvall
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
H F KungR Ackerhalt
© 2022 Meta ULC. All rights reserved