PET brain mapping study of auditory verbal supraspan memory versus visual fixation in schizophrenia

Biological Psychiatry
R GanguliE Bennington

Abstract

Changes in regional cerebral blood flow (rCBF), associated with performance of an auditory verbal supraspan memory task, were studied in eight remitted DSM-III-R schizophrenic patients and eight pair-wise matched normal controls. Four positron emission tomography (PET) scans, using the [15O]-H2O technique, were acquired: two while subjects fixated a cross hair and two while performing a verbal free-recall supraspan memory task. Task performance showed typical patterns of recency and primacy effects in both groups; however, patients performed more poorly than controls on the primary (working) memory aspect of the task. Regions showing rCBF changes overlapped in both groups and were similar to those seen in previous studies of normals; however, patients had smaller increases in rCBF than controls in frontal and superior temporal cortical regions bilaterally. Our results suggest that remitted patients with schizophrenia demonstrate impairments of capacity-limited information processing, which may be related to metabolic dysfunction within a distributed network of brain structures, including the prefrontal and temporal cortical regions; however, dysfunction limited to the frontal cortex cannot be ruled out by the results of this ex...Continue Reading

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Citations

Jul 8, 1999·Biological Psychiatry·D MalaspinaR Van Heertum
Jun 20, 2002·Schizophrenia Research·Rohan GanguliMark Mintun
Sep 27, 2003·Psychiatry Research·Andreas J FallgatterMartin J Herrmann
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Jul 4, 2006·Biological Psychiatry·Martin LepageSamarthji Lal
Jan 7, 2003·Biological Psychiatry·Anthony P WeissStephan Heckers
Sep 28, 2002·Human Brain Mapping·Natalia OjedaSalvador Cervera-Enguix
Jan 16, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Lisa T Eyler ZorrillaGregory G Brown
Dec 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Amélie M Achim, Martin Lepage
Aug 3, 2007·International Review of Psychiatry·J D RaglandC S Carter
May 2, 2000·The British Journal of Psychiatry : the Journal of Mental Science·D H BlackwoodK P Ebmeier
Oct 8, 2008·The British Journal of Nutrition·Karin VågstrandAnna Karin Lindroos

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