PET-CT vs contrast-enhanced CT: what is the role for each after chemoradiation for advanced oropharyngeal cancer?

Head & Neck
Amy Y ChenRagheev Halkar

Abstract

The aim of our study was to assess the utility of positron emission tomography (PET) and 2 fluoro-2-deoxy-D-glucose coupled with neck CT compared with contrast-enhanced CT in predicting persistent cancer either at the primary site or cervical lymphatics in patients with oropharyngeal cancer treated with concurrent chemoradiation Thirty consecutive patients underwent clinical examination, PET-CT, and contrast-enhanced CT to assess response after the completion of the treatment. The outcome variable was positive tissue diagnosis or negative disease at 6 months. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated for the primary site as well as cervical disease. Contrast-enhanced CT alone showed the best accuracy in detecting disease at the primary site after treatment (85.7%). Accuracy in evaluating residual tumor in the cervical lymphatics for contrast-enhanced CT and PET-CT was 59.3% and 74.1%, respectively. For evaluating the neck, PET-CT and contrast-enhanced CT demonstrated 100% NPV, but the PPV was 36.3% and 26.6%, respectively. In this preliminary study, PET-CT seems to be superior to contrast-enhanced CT in predicting persistent disease in the neck after...Continue Reading

References

Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J S CooperS Silverman
Apr 1, 1995·The Annals of Otology, Rhinology, and Laryngology·W F McGuirtJ O Cappellari
Sep 30, 1993·International Journal of Radiation Oncology, Biology, Physics·L ChaikenR Parker
Jun 1, 1997·Clinical Otolaryngology and Allied Sciences·W L WongM Maisey
May 7, 1998·Head & Neck·W F McGuirtK R Geisinger
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V J LoweJ W Fletcher
Apr 29, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M LapelaH Minn
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·N R SchechterK K Ang
Dec 17, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Yoshimasa KitagawaYoshiharu Yonekura
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·John W RogersJames O Cappellari

❮ Previous
Next ❯

Citations

Feb 18, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Shu-Hang NgKang-Hsing Fan
Aug 20, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Tejpal GuptaAshwini Budrukkar
Feb 4, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·James Malone, K Thomas Robbins
Apr 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benjamin J MoellerDavid L Schwartz
Mar 19, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Kevin G KingLale Kostakoglu
Apr 6, 2012·Japanese Journal of Radiology·Joji KawabeSusumu Shiomi
Dec 4, 2012·Neuroimaging Clinics of North America·Kristen L Baugnon, Jonathan J Beitler
Oct 2, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·J YooC Walker-Dilks
Nov 18, 2008·Hematology/oncology Clinics of North America·Sandro V PorcedduRodney J Hicks
Jun 19, 2008·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·M G IslesH M Mehanna
Feb 27, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Nils HelsenSigrid Stroobants
Nov 22, 2017·Head & Neck·Antoine EskanderUNKNOWN Education Committee of American Head and Neck Society (AHNS)
Feb 28, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shlomo A KoyfmanF Christopher Holsinger
Feb 14, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mischa de RidderA Al-Mamgani
Nov 22, 2019·The Cochrane Database of Systematic Reviews·Beverley L HøegChristoffer Johansen
Aug 31, 2020·Laryngoscope Investigative Otolaryngology·Avanti Verma, Amy Y Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.