PET examination of the monoamine transporter with [11C]beta-CIT and [11C]beta-CFT in early Parkinson's disease

Synapse
J O RinneU K Rinne

Abstract

The monoamine transporter was studied in 4 healthy controls and 5 patients with early Parkinson's disease (PD), who had not received any antiparkinsonian medication, by means of positron emission tomography (PET) using two novel ligands, [11C]beta-CIT and [11C]beta-CFT. Both ligands showed highest uptake in the striatum. There was intermediate accumulation of activity in the thalamus and midbrain, which was more marked for [11C]beta-CIT than for [11C]beta-CFT. In the cortical areas, uptake of both ligands was not different from that seen in the cerebellum. In the controls, the putamen-to-cerebellum and caudate-to-cerebellum ratios for [11C]beta-CFT were higher than those for [11C]beta-CIT (putamen: 3.15 +/- 0.39 for [11C]beta-CFT, and 1.84 +/- 0.10 for [11C]beta-CIT; caudate: 3.15 +/- 0.31 for [11C]beta-CFT, and 1.95 +/- 0.17 for [11C]beta-CIT). Reduction from mean control value in PD patients was greater for [11C]beta-CFT (45% in the putamen contralateral to the predominant symptoms, P < 0.001) than for [11C]beta-CIT (20%, P > 0.05). [11C]beta-CFT uptake in the caudate nucleus was also diminished in PD patients (to 80% of the control mean, P < 0.05), whereas [11C]beta-CIT was within normal range (reduced to 90% of the control ...Continue Reading

References

Jan 1, 1978·Annual Review of Neuroscience·R Y Moore, F E Bloom
Jun 28, 1992·Annals of the New York Academy of Sciences·J W BojaM J Kuhar
Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Jan 1, 1989·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·M R KilbournD E Kuhl
Aug 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·K L LeendersC D Marsden
Dec 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S Patlak, R G Blasberg
Feb 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·E S GarnettG Firnau
Nov 11, 1983·European Journal of Pharmacology·C PimouleS Z Langer
Feb 1, 1995·Nuclear Medicine and Biology·K NågrenP Lehikoinen
Jan 1, 1993·Journal of Neural Transmission. General Section·T BrückeI Podreka
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R B InnisS Wang

❮ Previous
Next ❯

Citations

Jan 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·A BrashearG D Hutchins
Oct 31, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Jan Booij, Paul Kemp
Nov 1, 1996·Nuclear Medicine and Biology·Q H Zheng, G K Mulholland
Aug 17, 2002·Methods : a Companion to Methods in Enzymology·Marc LaruelleYiyun Huang
Apr 1, 1997·Parkinsonism & Related Disorders·J O RinneH Kilpelainen
Nov 24, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·J O RinneO Solin
May 22, 2007·Science & Practice Perspectives·Joanna S FowlerLinda Chang
May 10, 2012·Journal of Biomedicine & Biotechnology·Lie-Hang ShenYu-Chin Tseng
Jun 5, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·G K WenningW Poewe
Oct 1, 2009·Journal of Movement Disorders·Juha O Rinne
Jul 21, 2009·Trends in Pharmacological Sciences·Victor W Pike
Jun 16, 2009·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller
Jul 13, 2005·Acta Neurologica Scandinavica·M MishinaY Katayama
Apr 3, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Haifeng HouHong Zhang
Feb 19, 2014·Nuclear Medicine and Biology·Jonathon A NyeMark M Goodman
May 14, 2008·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Masahiro Mishina
Sep 5, 2020·The International Journal of Neuroscience·Wei LinYu-Hai Wang
Dec 5, 2003·Acta Neurologica Scandinavica·J O RinneM Partinen
Feb 19, 2000·Annals of Medicine·J O Rinne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.