PET hypermetabolism in medically resistant childhood epilepsy: Incidence, associations, and surgical outcome

Epilepsia
Lalit BansalP Jayakar

Abstract

We observed several children with medically resistant epilepsy demonstrating focal positron emission tomography (PET) hypermetabolism, a finding rarely reported and of questionable significance. We therefore retrospectively reviewed the incidence of hypermetabolic PET, and its relationship to electroencephalography (EEG) and magnetic resonance imaging (MRI) findings, and to the outcome of epilepsy surgery. We retrospectively reviewed 498 PET brain studies in patients with medically resistant childhood epilepsy for evidence of hypermetabolism. In patients with PET hypermetabolism, we correlated metabolic abnormality with the scalp EEG and MRI findings. In a subset of patients who underwent surgical resection, we further correlated the PET findings with histopathologic and surgical outcomes. Focal PET hypermetabolism was identified in 33 (6.6%) of 498 studies. The region of hypermetabolism correlated with a spike count of ≥10 per minute in 26 of 32 concomitant scalp EEG studies and 18 of 21 lesions evident on MRI. In 17 patients who underwent surgical resection, PET hypermetabolism further correlated with regions revealing almost continuous epileptiform discharges on the intracranial EEG and with histopathologically malformative ...Continue Reading

References

Jan 1, 1993·Pediatric Neurology·H T ChuganiM E Phelps
Feb 7, 2001·Journal of Computer Assisted Tomography·S K KimB K Han
Jan 31, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Joon Young ChoiSang Eun Kim
Feb 8, 2005·Radiologic Clinics of North America·Andrew B Newberg, Abass Alavi
Apr 25, 2006·Brain & Development·Aimee F LuatRobert Rothermel
Nov 7, 2009·Clinical Nuclear Medicine·Roland TalanowGuiyun Wu
Nov 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ajay KumarHarry T Chugani

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Citations

Mar 21, 2018·Frontiers in Molecular Neuroscience·Hua TaoKeshen Li
Sep 15, 2018·AJNR. American Journal of Neuroradiology·Y SakaguchiJ Natsume
Nov 22, 2018·Frontiers in Cellular Neuroscience·Jenny B Koenig, Chris G Dulla
Feb 23, 2020·Frontiers in Neurology·Tatjana Traub-WeidingerEkaterina Pataraia
Jul 26, 2019·Nature Reviews. Neurology·Maeike ZijlmansNicole van Klink
Jul 22, 2020·World Neurosurgery·Ibrahim HussainCaitlin E Hoffman
Jan 21, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yuankai ZhuMei Tian
Jul 31, 2021·Pediatric Neurology·Fernando N GalanRaj D Sheth

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