PET imaging of cholinergic deficits in rats using [18F]fluoroethoxybenzovesamicol ([18F]FEOBV)

NeuroImage
Maxime J ParentPedro Rosa-Neto

Abstract

[(18)F]fluoroethoxybenzovesamicol ([(18)F]FEOBV) is one of the most promising radioligands for imaging the vesicular ACh transporter (VAChT) with positron emission tomography (PET). We report here that this method can detect subtle cholinergic terminals losses such as those associated with aging, or those following a partial lesion of the nucleus basalis magnocellularis (NBM). Twenty-one adult rats were evenly distributed in three groups including 1) aged rats (18 months); 2) young rats (3 months); and 3) rats with unilateral lesion of the NBM, following a local stereotaxic infusion of 192 IgG-saporin. In both normal and lesioned rats, our results revealed the highest [(18)F]FEOBV binding to be in the striatum, followed by similar values in both frontal cortex and thalamus, while lower values were observed in both hippocampus and temporo-parietal cortex. This binding distribution is consistent with the known anatomy of brain cholinergic systems. In the lesioned rats, [(18)F]FEOBV binding was found to be reduced mostly in the ventral frontal cortex on the side of the lesion, but some reductions were also observed in the homologous region of the contralateral hemisphere. Aging was found to be associated with a [(18)F]FEOBV bindin...Continue Reading

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Citations

Dec 11, 2013·International Journal of Molecular Imaging·Maxime J ParentPedro Rosa-Neto
Jul 6, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Sara BergmanGunnar Antoni
Jun 21, 2015·Current Neurology and Neuroscience Reports·Darryl BannonDoris J Doudet
Aug 21, 2013·NeuroImage·Paul Cumming
Feb 6, 2019·Annals of Neurology·Nicolaas I BohnenMartijn L T M Müller
Feb 11, 2020·Frontiers in Neuroscience·J Miguel Cisneros-FrancoÉtienne de-Villers-Sidani
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Jan 8, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Anna SchildtJanine Doorduin
Dec 8, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nisha K RamakrishnanAren van Waarde
Feb 23, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Martin SarterEryn Donovan
Jul 5, 2018·Cell Reports·Taylor W SchmitzUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 1, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Meghmik AghourianMarc-André Bedard

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