PET imaging of neurotransmission using direct parametric reconstruction.

NeuroImage
Yoann PetibonMarc D Normandin

Abstract

Receptor ligand-based dynamic Positron Emission Tomography (PET) permits the measurement of neurotransmitter release in the human brain. For single-scan paradigms, the conventional method of estimating changes in neurotransmitter levels relies on fitting a pharmacokinetic model to activity concentration histories extracted after PET image reconstruction. However, due to the statistical fluctuations of activity concentration data at the voxel scale, parametric images computed using this approach often exhibit low signal-to-noise ratio, impeding characterization of neurotransmitter release. Numerous studies have shown that direct parametric reconstruction (DPR) approaches, which combine image reconstruction and kinetic analysis in a unified framework, can improve the signal-to-noise ratio of parametric mapping. However, there is little experience with DPR in imaging of neurotransmission and the performance of the approach in this application has not been evaluated before in humans. In this report, we present and evaluate a DPR methodology that computes 3-D distributions of ligand transport, binding potential (BPND) and neurotransmitter release magnitude (γ) from a dynamic sequence of PET sinograms. The technique employs the linea...Continue Reading

References

Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonD J Nutt
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A BreierD Pickar
Apr 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R E CarsonW C Eckelman
Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Jun 2, 1998·Nature·M J KoeppP M Grasby
Nov 11, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C J Endres, R E Carson
Aug 11, 2001·Science·R de la Fuente-FernándezA J Stoessl
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Aug 3, 2002·The American Journal of Psychiatry·Harvey S SingerDean F Wong
Oct 9, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masanori IchiseRichard E Carson
Sep 16, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masanori IchiseRichard E Carson
May 1, 1994·Physics in Medicine and Biology·H H BarrettB M Tsui
May 14, 2005·IEEE Transactions on Medical Imaging·M E KamasakK Sauer
Jul 16, 2005·Biological Psychiatry·Diana MartinezAnissa Abi-Dargham
Mar 16, 2007·IEEE Transactions on Medical Imaging·Cristian C ConstantinescuEvan D Morris
Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dean F WongAnthony A Grace
Feb 5, 2008·NeuroImage·André J W van der KouweBruce Fischl
Jan 1, 1996·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·J A Fessler
Oct 10, 2008·Medical Physics·Charalampos TsoumpasKris Thielemans
Mar 3, 2009·Biological Psychiatry·Sylvia M L CoxMarco Leyton
Apr 11, 2009·Synapse·Usoa E BustoLaurie A Zawertailo
May 19, 2009·IEEE Transactions on Medical Imaging·Guobao Wang, Jinyi Qi
Feb 17, 2010·Physics in Medicine and Biology·Guobao Wang, Jinyi Qi
Aug 4, 2010·Archives of General Psychiatry·Sarah C LidstoneA Jon Stoessl
Aug 30, 2012·IEEE Transactions on Medical Imaging·Jianhua YanRichard E Carson
Aug 31, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jenny CeccariniKoen Van Laere
Jan 8, 2014·Theranostics·Guobao Wang, Jinyi Qi
Oct 4, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David Izquierdo-GarciaCiprian Catana
Nov 2, 2014·Physics in Medicine and Biology·Andrew J Reader, Jeroen Verhaeghe
Sep 1, 2016·IEEE Transactions on Medical Imaging·Jieqing JiaoSebastien Ourselin
Apr 6, 2017·Physics in Medicine and Biology·Yoann PetibonJinsong Ouyang
Jan 20, 2019·Nature Communications·Rachel N LippertHeiko Backes
Sep 21, 2019·NeuroImage·Alain Dagher, Nicola Palomero-Gallagher

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Methods Mentioned

BETA
imaging technique

Software Mentioned

ntPET
DPR
lp
LSRRM
OSEM
FSL

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