PET imaging shows no changes in TSPO brain density after IFN-α immune challenge in healthy human volunteers.

Translational Psychiatry
M A NettisCarmine M Pariante

Abstract

Depression is associated with peripheral inflammation, but its link with brain microglial activity remains unclear. In seven healthy males, we used repeated translocator protein-Positron Emission Tomography (TSPO-PET) dynamic scans with [11C]PBR28 to image brain microglial activation before and 24 h after the immune challenge interferon (IFN)-α. We also investigated the association between changes in peripheral inflammation, changes in microglial activity, and changes in mood. IFN-α administration decreased [11C]PBR28 PET tissue volume of distribution (Vt) across the brain (-20 ± 4%; t6 = 4.1, p = 0.01), but after correction for radioligand free-plasma fraction there were no longer any changes (+23 ± 31%; t = 0.1, p = 0.91). IFN-α increased serum IL-6 (1826 ± 513%, t6 = -7.5, p < 0.001), IL-7 (39 ± 12%, t6 = -3.6, p = 0.01), IL-10 (328 ± 48%, t6 = -12.8, p < 0.001), and IFN-γ (272 ± 64%, t6 = -7.0, p < 0.001) at 4-6 h, and increased serum TNF-α (49 ± 7.6%, t6 = -7.5, p < 0.001), IL-8 (39 ± 12%, t6 = -3.5, p = 0.013), and C-reactive protein (1320 ± 459%, t6 = -7.2, p < 0.001) at 24 h. IFN-α induced temporary mood changes and sickness symptoms after 4-6 h, measured as an increase in POMS-2 total mood score, confusion and fatigue,...Continue Reading

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Citations

Sep 26, 2020·CNS Drugs·Ayushi Anna DineshAnthony C Vernon
Jan 31, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Julia J SchubertFederico E Turkheimer
Jan 29, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maria Antonietta NettisValeria Mondelli
Oct 2, 2020·Brain, Behavior, and Immunity·Eric A WoodcockRobert H Pietrzak
Sep 28, 2020·Neurochemistry International·Kazuya KikutaniHidenori Aizawa
Apr 12, 2021·Brain, Behavior, and Immunity·Annemieke M Peters van TonPeter Pickkers
Jul 1, 2021·Oxford Open Immunology·Valeria Mondelli, Carmine M Pariante

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