PET-measured heterogeneity in longitudinal myocardial blood flow in response to sympathetic and pharmacologic stress as a non-invasive probe of epicardial vasomotor dysfunction.

European Journal of Nuclear Medicine and Molecular Imaging
Thomas H SchindlerHeinrich R Schelbert

Abstract

We investigated whether a myocardial perfusion gradient during pharmacologically induced hyperemia also occurred during sympathetic stimulation with cold pressor testing (CPT), which commonly induces a paradoxical coronary vasoconstriction in individuals with coronary risk factors. Myocardial blood flow (MBF) was measured in absolute units (ml/g/min) with 13N-ammonia and PET at rest, during CPT, and during pharmacologic vasodilation in 59 participants with coronary risk factors ("at risk") and in 43 healthy individuals (controls). MBF was assessed globally as mean MBF, and in the mid and mid-distal myocardium of the left ventricle (LV). A decrease in MBF from mid to mid-distal LV myocardium was defined as MBF difference indicative of a perfusion gradient. The change in mean MBF to CPT (DeltaMBF) in the at-risk group was significantly reduced compared with controls (0.05+/-0.19 vs 0.31+/-0.20 ml/g/min, p<0.0001), whereas mean MBF during pharmacologic vasodilation in the at-risk group tended to be lower than in controls (1.72+/-0.71 vs 2.00+/-0.64 ml/g/min, p=NS). Absolute MBFs during CPT and pharmacologic vasodilation were significantly lower in the mid-distal than in the mid LV myocardium, resulting in a significant MBF differe...Continue Reading

References

Jun 14, 1979·The New England Journal of Medicine·G A Diamond, J S Forrester
Oct 1, 1992·Journal of the American College of Cardiology·S Y ChanH R Schelbert
Sep 1, 1989·Circulation·H DrexlerT Bonzel
Jun 1, 1981·Circulation·H R SchelbertD E Kuhl
Oct 2, 2002·Journal of the American College of Cardiology·Ahmed TawakolHenry Gewirtz
Dec 6, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Birger HesseLionel H Opie
Aug 4, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Christophe A WyssPhilipp A Kaufmann
Aug 18, 2004·Circulation·Thomas H SchindlerHeinrich R Schelbert
Jan 13, 2005·Diabetologia·Z Y FangT H Marwick

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Citations

Mar 6, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Thomas H SchindlerHeinrich R Schelbert
Aug 16, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Thomas H SchindlerHeinrich R Schelbert
Nov 26, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Nagara TamakiMasanao Naya
Jun 4, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Heinrich R Schelbert
Jul 27, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ines ValentaThomas H Schindler
Aug 7, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas H SchindlerHeinrich R Schelbert
Sep 11, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas H SchindlerHeinrich R Schelbert
Nov 21, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas H Schindler, Heinrich H Schelbert
Jul 24, 2012·EJNMMI Research·Romain ModzelewskiPierre Vera
Jun 21, 2014·Seminars in Nuclear Medicine·Thomas H SchindlerVasken Dilsizian
Dec 30, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas Hellmut Schindler
Dec 29, 2009·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Romain ModzelewskiPierre Vera
Mar 25, 2009·Cardiology Clinics·Heinrich R Schelbert
Feb 4, 2012·European Journal of Clinical Investigation·Reza GolestaniRudi A J O Dierckx
Oct 15, 2011·Journal of the American College of Cardiology·Masanao NayaMarcelo F Di Carli
Nov 25, 2014·Current Cardiology Reports·Ines ValentaThomas H Schindler
Jun 22, 2016·European Heart Journal Cardiovascular Imaging·Ines ValentaThomas H Schindler
Mar 21, 2007·Circulation·Marcelo F Di Carli, Rory Hachamovitch
Aug 5, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Maria SciammarellaElias H Botvinick
Aug 5, 2017·Frontiers in Cardiovascular Medicine·Thorsten M LeuckerThomas Hellmut Schindler
Aug 16, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Dominik A SteffenRonny R Buechel
Jun 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paolo G Camici, Ornella E Rimoldi

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