Abstract
Targeted therapies often depend on the expression of the target present in the tumor. This expression can be difficult to ascertain in widespread metastases. (18)F-FDG PET/CT, although sensitive, is nonspecific for particular tumor markers. Here, we compare the use of a human epidermal growth factor receptor 2 (HER2)-specific (18)F-Z(HER2)(:342)-Affibody and (18)F-FDG in HER2-expressing pulmonary metastases in a murine model of breast cancer. The lung metastasis model was established by intravenous injection of MDA-MB-231(HER2)-Luc human breast cancer cells into the tail vein. Bioluminescence imaging was used to evaluate metastasis progression. Uptake of (18)F-Z(HER2)(:342)-Affibody and (18)F-FDG was confirmed by coregistration of the PET images with MR and CT images. At the end of the study, the presence of neoplastic cells and HER2 expression in lung tissues, and distribution of the tracer, were assessed ex vivo by immunohistochemistry and autoradiography. (18)F-Z(HER2)(:342)-Affibody successfully targeted HER2-positive lesions in the lung and allowed detection of metastases as early as 9 wk after injection of cells. In contrast, (18)F-FDG uptake was often masked by surrounding inflammatory changes and was nonspecific for HER...Continue Reading
References
Oct 19, 2004·Radiologic Clinics of North America·Rakesh Kumar, Abass Alavi
Aug 18, 2005·British Journal of Cancer·J ZidanA Hadary
Mar 3, 2007·Cancer Research·Anna OrlovaJoachim Feldwisch
Apr 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mangal DandekarSanjiv S Gambhir
Dec 25, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Gabriela Kramer-MarekJacek Capala
Feb 22, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·James W FletcherAnthony F Shields
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joel R GarbowMing You
Jun 3, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Judith E FloresSimon-Peter Williams
Sep 23, 2008·Expert Opinion on Pharmacotherapy·Giulio MetroAlessandra Fabi
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qizhen CaoXiaoyuan Chen
Jun 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gabriela Kramer-MarekJacek Capala
Sep 4, 2009·Journal of Fluorine Chemistry·Dale O KiesewetterJacek Capala
Dec 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paula R PohlmannRay Mernaugh
Apr 15, 2010·FEBS Letters·J LöfblomF Y Frejd
Jul 29, 2010·Contrast Media & Molecular Imaging·Inneke WillekensJohan de Mey
Aug 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Charles EigenbrotTorleif Härd
Oct 5, 2010·Translational Oncology·Lakshmi SampathEva M Sevick-Muraca
Feb 11, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alessandra FabiMarcella Mottolese
Citations
Jul 9, 2013·EJNMMI Research·Ulas BagciDaniel J Mollura
Sep 27, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raquel De SouzaChristine Allen
Jun 7, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marc S RamirezJames A Bankson
May 23, 2014·Computers in Biology and Medicine·Brent FosterDaniel J Mollura
Jun 30, 2015·Bioconjugate Chemistry·Daliang LiWen-hong Li
Aug 5, 2017·International Journal of Molecular Sciences·Alicja M Sochaj-GregorczykJacek Otlewski
Oct 9, 2019·The British Journal of Radiology·Yuping XuMin Yang
Jul 25, 2019·Journal of Labelled Compounds & Radiopharmaceuticals·Peter B IvesonJulian Grigg
Jul 21, 2016·Nuclear Medicine Communications·Hao LiuMei Tian
May 27, 2016·Journal of Immunotherapy·Alicja M Sochaj-GregorczykJacek Otlewski
Sep 27, 2018·Oncology Letters·Yang YangJianfang Wang
Jun 22, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Nina ZhouZhi Yang
Jun 5, 2020·EJNMMI Research·Yuping XuMin Yang
Feb 14, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carlos D MartinsGabriela Kramer-Marek
Feb 5, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sebastian TrousilEric O Aboagye
May 20, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wejdan M ArifGert Luurtsema
Apr 9, 2018·Medical Image Analysis·Ziyue XuUlas Bagci
May 14, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gabriela Kramer-Marek, Wim J G Oyen
Oct 12, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias GlaserDuncan Hiscock
Mar 24, 2020·Chemical Reviews·Weijun WeiWeibo Cai