PET of tumors expressing gastrin-releasing peptide receptor with an 18F-labeled bombesin analog

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Ingrid DijkgraafOtto C Boerman

Abstract

The gastrin-releasing peptide receptor (GRPR) is overexpressed in human prostate cancer. Bombesin (BBN) is a neurotransmitter of 14 amino acids and binds with selectivity and with high affinity to GRPRs. We have synthesized a NOTA-conjugated bombesin derivative, NOTA-8-Aoc-BBN(7-14)NH(2), to label this analog with (18)F using the new Al(18)F method. In this study, the GRPR-targeting potential of (18)F-labeled NOTA-8-Aoc-BBN(7-14)NH(2) was studied using (68)Ga-NOTA-8-Aoc-BBN(7-14)NH(2) as a reference. The NOTA-conjugated bombesin analog was synthesized and radiolabeled with (68)Ga or (18)F. For (18)F labeling, we used our new 1-pot, 1-step method. The labeled product was purified by reversed-phase high-performance liquid chromatography. The log P values of the radiotracers were determined. The tumor-targeting characteristics of the compounds were assessed in mice with subcutaneously growing PC-3 xenografts. GRPR-binding specificity was studied by coinjection of an excess of unlabeled NOTA-8-Aoc-BBN(7-14)NH(2). Small-animal PET/CT images were acquired. NOTA-8-Aoc-BBN(7-14)NH(2) could be efficiently labeled with (18)F or with (68)Ga. NOTA-8-Aoc-BBN(7-14)NH(2) was labeled with (18)F in a single step, with 50%-90% yield. Radiolabeli...Continue Reading

References

Sep 30, 1988·Biochemical and Biophysical Research Communications·R B Martin
May 1, 1982·Peptides·T W MoodyR T Jensen
Jan 29, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Berthold NockTheodosia Maina
Jun 10, 2004·Cancer Biotherapy & Radiopharmaceuticals·Alexandra VarvarigouGiuseppe De Vincentis
Jan 31, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Hanwen ZhangHelmut R Maecke
Feb 9, 2007·European Journal of Nuclear Medicine and Molecular Imaging·M de VisserM de Jong
Jul 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Adam F PrasanphanichCharles J Smith
Jan 14, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Eric P VisserOtto C Boerman
May 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·William J McBrideDavid M Goldenberg
Feb 13, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Peter LavermanOtto C Boerman
Feb 26, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Rogier P J SchroederMarion de Jong
Jun 15, 2010·Bioconjugate Chemistry·William J McBrideDavid M Goldenberg
Feb 16, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kimberly A LearsBuck E Rogers
Aug 3, 2011·Bioconjugate Chemistry·Christopher A D'SouzaDavid M Goldenberg

❮ Previous
Next ❯

Citations

Jun 21, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Maria Picchio, Morand Piert
May 9, 2013·EJNMMI Research·William J McBrideDavid M Goldenberg
Jan 7, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Yuping XuYongjun Yan
Aug 22, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Neeta Pandit-TaskarSteven M Larson
Dec 11, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Susan Richter, Frank Wuest
Jul 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zohreh VarastehAnna Orlova
Jul 18, 2014·PET Clinics·Maarten BromWim J G Oyen
Apr 23, 2013·Nuclear Medicine and Biology·Morten PerssonAndreas Kjaer
Nov 6, 2012·Advanced Drug Delivery Reviews·Yang ZhouMartin W Brechbiel
Aug 12, 2014·Contrast Media & Molecular Imaging·Benjamin P BurkeStephen J Archibald
Apr 15, 2014·Contrast Media & Molecular Imaging·Donghui PanMin Yang
Sep 10, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A CochetF Brunotte
Aug 29, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sarah Marie SchwarzenböckBernd Joachim Krause
Mar 17, 2016·Expert Opinion on Therapeutic Targets·Paola MorenoRobert T Jensen
Nov 9, 2016·Seminars in Nuclear Medicine·David M SchusterStefano Fanti
Feb 26, 2016·Natural Product Reports·C L CharronL G Luyt
Nov 7, 2017·World Journal of Radiology·Jessica G ZarzourSoroush Rais-Bahrami
Dec 6, 2017·Contrast Media & Molecular Imaging·Geert HendrikxIngrid Dijkgraaf
Nov 10, 2015·Chemical Society Reviews·Kantapat ChansaenpakFrançois P Gabbaï
Dec 20, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Lucia BarattoAndrei Iagaru
Mar 20, 2013·Nature Reviews. Urology·Rosalba MansiJean C Reubi
Jan 11, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Peter LavermanOtto C Boerman
May 29, 2013·Nature Reviews. Urology·Hanneke J M MeijerJohannes H A M Kaanders
May 3, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Youcai LiKai Chen
Nov 4, 2017·Contrast Media & Molecular Imaging·Donghui PanMin Yang
Aug 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cyril FersingBenjamin Guillet
Nov 22, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kristell L S ChatalicMarion de Jong
Jun 9, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Krishan Kumar
Oct 12, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias GlaserDuncan Hiscock
Nov 8, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yang LiuZhen Cheng
Jul 12, 2016·Bioconjugate Chemistry·Yao SunXuechuan Hong
Aug 27, 2021·EJNMMI Radiopharmacy and Chemistry·Stephen J Archibald, Louis Allott

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bioconjugate Chemistry
Christopher A D'SouzaDavid M Goldenberg
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
William J McBrideDavid M Goldenberg
Dalton Transactions : an International Journal of Inorganic Chemistry
Gareth E SmithPhilip J Blower
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Peter LavermanOtto C Boerman
© 2021 Meta ULC. All rights reserved