Abstract
Positron-emission tomography (PET) has been used extensively in the clinic for cancer diagnosis, for staging and for monitoring of therapeutic efficacy. PET has not, however, been used extensively in contemporary animal cancer models. Until recently, appropriate instrumentation was not available and the expertise and knowledge necessary to perform PET analyses in murine models has not been widespread. The fabrication of microPET instruments with appropriate resolution for murine experiments has lead to the establishment of non-invasive techniques for functional imaging. The development of "PET reporter genes" whose activity can be monitored in living animals, based on the reporter gene-dependent sequestration of positron-emitting "PET reporter probes," has lead to innovative analyses of gene expression in transgenic animals, to methods to monitor the location, magnitude and duration of expression for gene therapy vectors and to the ability to non-invasively track the targeting, viability and expansion of cellular therapeutics.
Citations
Aug 6, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Chris SuckowDavid Stout
Oct 20, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Christopher M HineVera Gorbunova
Jun 21, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jani Kristian RätySeppo Ylä-Herttuala
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Melissa N McCrackenOwen N Witte
Nov 15, 2011·The Journal of Biological Chemistry·Dean O CampbellCaius G Radu
Jun 5, 2008·BMC Biotechnology·Leonardo D'AiutoJ Richard Chaillet
May 27, 2008·Journal of Molecular Endocrinology·Joanna E Burdette
Dec 19, 2008·Critical Reviews in Oncology/hematology·Dimitri PapathanassiouHervé Curé
Sep 16, 2008·Academic Radiology·Sergey MagnitskyHarish Poptani
Dec 7, 2006·Neuroimaging Clinics of North America·Dawid Schellingerhout
Jan 14, 2009·The Journal of Gene Medicine·Linh PhamStephen J Russell
Feb 16, 2008·Immunological Reviews·Evan D Nair-GillOwen N Witte
Apr 25, 2006·Nuclear Medicine and Biology·Chung-Shan YuChien-Hung Yeh
Feb 5, 2008·The Oncologist·David S BossJan H M Schellens
Dec 21, 2016·Nuclear Medicine and Molecular Imaging·Min Hwan KimJoo Hyun Kang
Sep 29, 2017·Frontiers in Immunology·Prakash Gangadaran, Byeong-Cheol Ahn
Nov 24, 2020·OncoTargets and Therapy·Xiaofeng LiWengui Xu
Dec 1, 2007·Journal of Medicinal Chemistry·Satish K ChitneniGuy M Bormans
Jan 9, 2008·Bioconjugate Chemistry·Sofie CelenGuy Bormans
May 31, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paul C TumehAntoni Ribas
May 25, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elise R RobinsonSanjiv S Gambhir
Aug 24, 2021·ACS Pharmacology & Translational Science·Natalia J MartinezJames Inglese
Feb 15, 2007·Journal of Medicinal Chemistry·Satish K ChitneniGuy M Bormans
Jun 12, 2009·Bioorganic & Medicinal Chemistry·Sofie CelenGuy Bormans