PET-specific parameters and radiotracers in theoretical tumour modelling

Computational and Mathematical Methods in Medicine
Matthew JenningsEva Bezak

Abstract

The innovation of computational techniques serves as an important step toward optimized, patient-specific management of cancer. In particular, in silico simulation of tumour growth and treatment response may eventually yield accurate information on disease progression, enhance the quality of cancer treatment, and explain why certain therapies are effective where others are not. In silico modelling is demonstrated to considerably benefit from information obtainable with PET and PET/CT. In particular, models have successfully integrated tumour glucose metabolism, cell proliferation, and cell oxygenation from multiple tracers in order to simulate tumour behaviour. With the development of novel radiotracers to image additional tumour phenomena, such as pH and gene expression, the value of PET and PET/CT data for use in tumour models will continue to grow. In this work, the use of PET and PET/CT information in in silico tumour models is reviewed. The various parameters that can be obtained using PET and PET/CT are detailed, as well as the radiotracers that may be used for this purpose, their utility, and limitations. The biophysical measures used to quantify PET and PET/CT data are also described. Finally, a list of in silico models...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·W J KohT W Griffin
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·D M BrizelM W Dewhirst
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Jul 12, 2002·European Journal of Nuclear Medicine and Molecular Imaging·C BurgerG K Von Schulthess
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Farrokh DehdashtiMichael J Welch
Sep 27, 2003·Radiology·Gerald AntochLutz S Freudenberg
Sep 1, 2004·The Annals of Thoracic Surgery·Robert James CerfolioAlfred A Bartolucci
May 7, 2005·Physics in Medicine and Biology·Daniela ThorwarthMarkus Alber
Jun 7, 2005·Journal of Theoretical Biology·Kieran SmallbonePhilip K Maini
Dec 20, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Betty S PioDaniel H S Silverman
Jan 21, 2006·AJR. American Journal of Roentgenology·Osama MawlawiMarvin Chasen
Mar 22, 2006·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jung Min ChangJung-Gi Im
May 19, 2006·Cancer Research·Robert A GatenbyRobert J Gillies
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ambros J BeerMarkus Schwaiger
Aug 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Anna C PfannenbergSusanne M Eschmann
Oct 28, 2006·Physics in Medicine and Biology·Catherine J Kelly, Michael Brady
Jan 27, 2007·Radiology·Todd M BlodgettDavid W Townsend
Feb 14, 2007·Annals of Nuclear Medicine·Hiroshi WatabeMiho Shidahara
Oct 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Cristina NanniDomenico Rubello
Oct 9, 2007·Seminars in Nuclear Medicine·Sze Ting Lee, Andrew M Scott
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wei ChenTimothy Cloughesy
Feb 22, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lanell M PetersonKenneth A Krohn
Feb 22, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·James W FletcherAnthony F Shields
Aug 30, 2008·Journal of Theoretical Biology·Kieran SmallbonePhilip K Maini
Dec 19, 2008·Critical Reviews in Oncology/hematology·Dimitri PapathanassiouHervé Curé
Dec 23, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael MacManusBranislav Jeremic
May 8, 2009·Physics in Medicine and Biology·Wenli WangJohn L Humm
Jul 1, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Gilles MeesChristophe Van de Wiele
Aug 4, 2009·Seminars in Nuclear Medicine·Dominique DelbekeRichard L Wahl
Jun 23, 2010·AJR. American Journal of Roentgenology·Carmel G CroninMichael A Blake
Jul 24, 2010·Head & Neck·Stephan K HaerleSandro J Stoeckli
Jul 28, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Xiaomeng ZhangRobert J Gillies
Feb 16, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ludwig G StraussAntonia Dimitrakopoulou-Strauss
May 3, 2011·Annual Review of Biomedical Engineering·Thomas S DeisboeckVittorio Cristini
Aug 16, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Giampaolo TomasiEric Aboagye
Dec 8, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Do Won HwangSoonhag Kim
Sep 14, 2012·Physics in Medicine and Biology·Vikram Adhikarla, Robert Jeraj
Sep 14, 2012·Physics in Medicine and Biology·Benjamin TitzRobert Jeraj
Jun 19, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matt VanderhoekRobert Jeraj
Mar 13, 2014·Medical Image Analysis·Yixun LiuJianhua Yao

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Citations

Feb 1, 2017·Physics in Medicine and Biology·Mireia Crispin-OrtuzarJoseph O Deasy
Mar 31, 2016·World Journal of Radiology·Ammar A ChaudhryRobert Matthews
Jul 28, 2019·EJNMMI Research·Dániel S VeresKrisztián Szigeti

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Methods Mentioned

BETA
X-ray
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Software Mentioned

FMISO

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