PET study of brain acetylcholinesterase in cerebellar degenerative disorders

Movement Disorders : Official Journal of the Movement Disorder Society
Shigeki HiranoToshiaki Irie

Abstract

To elucidate characteristic changes of brain acetylcholinesterase (AChE) in cerebellar degenerative disorders. Eight patients with the cerebellar variant of multiple system atrophy (MSA-C), 7 patients with spinocerebellar ataxia type-3 (SCA-3), 3 patients with SCA-6, and 13 healthy age-matched volunteers participated in this study. Brain AChE activity was measured by [(11)C] N-methylpiperidin-4-yl propionate PET in all subjects. Brain AChE activities were significantly decreased in the thalamus (-27%) and the posterior lobe of cerebellar cortex (-36%) in patients with MSA-C and in the thalamus (-23%) in patients with SCA-3 compared with healthy controls (P < 0.01). Thalamic AChE activities of SCA-3 patients were negatively correlated with the unified Parkinson's disease rating scale motor subscore (P < 0.001). AChE activities were not significantly altered in the cerebral cortex in any disease group. Reduction of AChE activities in the thalamus and cerebellum in MSA and in the thalamus in SCA-3 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Apr 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·S J KishM Rebbetoy
Aug 1, 1980·Acta Neurologica Scandinavica·P SehestedO Kristensen
May 1, 1999·Journal of the Neurological Sciences·S GilmanG K Wenning
May 19, 2000·Yonsei Medical Journal·M S LeeC D Marsden
Dec 13, 2000·Neurology·B DuboisB Pillon
Apr 3, 2001·Nature Reviews. Neuroscience·H Soreq, S Seidman
Aug 10, 2002·NeuroImage·Fumihiko YasunoHinako Toyama
Nov 16, 2002·Archives of Neurology·Atsushi IshikawaShoji Tsuji
Jun 8, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Koichi SatoToshiaki Irie
Nov 10, 2004·Archives of Neurology·Yoshinari KawaiGen Sobue
Sep 15, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Christian BrenneisWerner Poewe

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Citations

Jun 19, 2010·Brain : a Journal of Neurology·Shigeki HiranoTetsuya Suhara
Jan 12, 2010·Behavioural Brain Research·Nicolaas I Bohnen, Roger L Albin
Feb 9, 2010·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Anelyssa D'AbreuFernando Cendes
Dec 3, 2010·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Márcia S de OliveiraGabriela Castellano
Aug 26, 2016·Reviews in the Neurosciences·Changzheng ZhangTifei Yuan
Nov 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Pablo AguiarJulia Cortés
Nov 29, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Tatsuya KikuchiToshiaki Irie
Apr 10, 2021·Journal of the Neurological Sciences·Meng-Ling ChenSheng-Han Kuo
Jun 20, 2021·Bioorganic & Medicinal Chemistry Letters·Murilo K A YonekawaEdson Dos A Dos Santos

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