PMID: 7581171Jul 1, 1995Paper

PET study of the distribution of [11C]fluoxetine in a monkey brain

Nuclear Medicine and Biology
C Y ShiueM F O'Rourke

Abstract

No-carrier-added [11C]fluoxetine (2) was synthesized by methylation of norfluoxetine (1) with [11C]H3I in 20% radiochemical yield in a synthesis time of 40 min from EOB with a specific activity of 0.48 Ci/microM (EOB). In vivo study in mouse indicated that the uptake of 2 in mouse tissues was high and the radioactivity remained constant throughout the study. The uptake of 2 in mouse brain was 4%/g. PET study in a Rhesus monkey also showed that the uptakes of 2 in different brain regions were similar and the retention of radioactivity in these regions remained constant throughout the study (80 min). Analysis of arterial plasma by HPLC showed that only 20% of radioactivity in the plasma remained as 2 at 30 min post-injection. These results suggest that the uptake of fluoxetine in monkey brain is probably not receptor mediated. Rather, blood flow, lipophilicity or other transport mechanisms may play a role in its uptake.

Citations

Feb 8, 2003·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Grace G ShiueChyng-Yann Shiue
Apr 1, 1997·Nuclear Medicine and Biology·Y Zea-PonceR B Innis
Aug 19, 2007·American Journal of Respiratory and Critical Care Medicine·Enrica FornaroJaques Belik
Jan 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D F Smith
Aug 8, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Ya-Yao HuangChyng-Yann Shiue
Nov 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N GinovartS Houle
Jul 28, 2007·Synapse·Betina ElfvingGitte M Knudsen
Apr 23, 2008·Chemical Reviews·Simon M AmetameyPius August Schubiger

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