PET/CT analysis of 21 patients with breast cancer: physiological distribution of 18 F-choline and diagnostic pitfalls

The Journal of International Medical Research
Fathinul Fikri Ahmad SaadBahunu Appanna

Abstract

Objectives 18F-choline is a useful tracer for detecting tumours with high lipogenesis. Knowledge of its biodistribution pattern is essential to recognise physiological variants. The aim of this study was to describe the physiologic distribution of 18F-choline and pitfalls in patients with breast cancer. Methods Twenty-one consecutive patients with breast cancer (10 premenopausal and 11 postmenopausal women; mean age, 52.82 ± 10.71 years) underwent 18F-choline positron emission tomography (PET)/computed tomography (CT) for staging. Whole-body PET/CT was acquired after 40 minutes of 18F-choline uptake. Acquired PET images were measured semiquantitatively. Results All patients showed pitfalls unrelated to breast cancer. These findings were predominantly caused by physiological glandular uptake in the liver, spleen, pancreas, bowels, axial skeleton (85%-100%), inflammation and benign changes (4.76%), appendicular skeleton (4.76%-19.049%), and site contamination (61.9%). In <1%, a concomitant metastatic neoplasm was found. The breast showed higher physiological uptake in premenopausal compared with postmenopausal woman (18F-choline maximum standardised uptake values [g/dL] of the right breast = 2.04 ± 0.404 vs 1.59 ± 0.97 and left b...Continue Reading

References

Aug 15, 2002·Biochemical and Biophysical Research Communications·Ana Ramírez de MolinaJuan Lacal
Jun 15, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Koen MertensIngeborg Goethals
Dec 18, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Ferdinando CalabriaOrazio Schillaci
Mar 16, 2012·The American Journal of Clinical Nutrition·Jian YanMarie A Caudill
Dec 26, 2013·Clinical Nuclear Medicine·Ferdinando CalabriaOrazio Schillaci

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Citations

Oct 28, 2019·Clinical Nuclear Medicine·Rakhee VatsaBhagwant Rai Mittal
Dec 6, 2018·Clinical Nuclear Medicine·Lea CuppariLaura Evangelista

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