PET/CT Imaging of Chemokine Receptors in Inflammatory Atherosclerosis Using Targeted Nanoparticles.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Hannah P LuehmannYongjian Liu

Abstract

Atherosclerosis is inherently an inflammatory process that is strongly affected by the chemokine-chemokine receptor axes regulating the trafficking of inflammatory cells at all stages of the disease. Of the chemokine receptor family, some specifically upregulated on macrophages play a critical role in plaque development and may have the potential to track plaque progression. However, the diagnostic potential of these chemokine receptors has not been fully realized. On the basis of our previous work using a broad-spectrum peptide antagonist imaging 8 chemokine receptors together, the purpose of this study was to develop a targeted nanoparticle for sensitive and specific detection of these chemokine receptors in both a mouse vascular injury model and a spontaneously developed mouse atherosclerosis model. The viral macrophage inflammatory protein-II (vMIP-II) was conjugated to a biocompatible poly(methyl methacrylate)-core/polyethylene glycol-shell amphiphilic comblike nanoparticle through controlled conjugation and polymerization before radiolabeling with (64)Cu for PET imaging in an apolipoprotein E-deficient (ApoE(-/-)) mouse vascular injury model and a spontaneous ApoE(-/-) mouse atherosclerosis model. Histology, immunohistoch...Continue Reading

References

May 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·Y NakashimaR Ross
Mar 17, 2004·Current Opinion in Lipidology·Christina A BursillDavid R Greaves
Oct 2, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Niels R VeillardFrançois Mach
Feb 10, 2006·The New England Journal of Medicine·Israel F Charo, Richard M Ransohoff
Jan 4, 2007·The Journal of Clinical Investigation·Frank TackeGwendalyn J Randolph
Apr 14, 2007·Current Pharmaceutical Design·A O KraaijeveldJ W Jukema
May 1, 2007·Atherosclerosis·Marlon P QuinonesSeema S Ahuja
Jun 30, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Randal J WestrickDaniel T Eitzman
Dec 26, 2007·Circulation·Matthias NahrendorfRalph Weissleder
Jun 21, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Alma ZerneckeChristian Weber
Dec 17, 2008·Nature Reviews. Drug Discovery·Richard Horuk
Jan 7, 2009·Expert Reviews in Molecular Medicine·Richard Horuk
Dec 17, 2009·Cardiovascular Research·Alma Zernecke, Christian Weber
Apr 21, 2011·The Journal of Clinical Investigation·Stephane PotteauxGwendalyn J Randolph
Oct 11, 2011·Nature Biotechnology·Florian LeuschnerMatthias Nahrendorf
Nov 4, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yongjian LiuMichael J Welch
Jan 17, 2012·Bioconjugate Chemistry·Yongjian Liu, Michael J Welch
Aug 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter Libby
Jan 1, 2013·Bioconjugate Chemistry·Eric D PresslyYongjian Liu
May 10, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yongjian LiuMichael J Welch
Aug 21, 2013·Artificial DNA, PNA & XNA·Raman BahalPeter M Glazer
Aug 27, 2013·Blood·Emmanuel L GautierGwendalyn J Randolph
Sep 3, 2013·Nature Reviews. Immunology·Kathryn J MooreEdward A Fisher
Dec 7, 2013·Theranostics·Moritz WildgruberAlma Zernecke
Mar 5, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hannah P LuehmannYongjian Liu
Jun 11, 2014·Nature Reviews. Cardiology·Jason M TarkinJames H F Rudd
Mar 21, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Maik DrechslerOliver Soehnlein

❮ Previous
Next ❯

Citations

Nov 11, 2017·Drug Delivery·Lingzhou ZhaoJinhua Zhao
Jun 29, 2018·Small·Linda C NoukeuKytai T Nguyen
Jan 6, 2018·Circulation Research·Lisa Honold, Matthias Nahrendorf
Mar 9, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yongjian Liu, Pamela K Woodard
Dec 15, 2017·Small·Cecilia Ka Wing ChanChung Hang Jonathan Choi
May 28, 2020·Antioxidants & Redox Signaling·Henry W West, Charalambos Antoniades
Sep 27, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jonathan VigneUNKNOWN Cardiovascular study group of the European Society of Molecular Imaging
Sep 13, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Evangelos K OikonomouCharalambos Antoniades
May 26, 2016·Molecular Medicine Reports·Yan-Feng LiuMing Qi
Mar 24, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Edwin C PrattJan Grimm
Mar 28, 2019·Frontiers in Medicine·Eric J MeesterMarion de Jong
Feb 23, 2020·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Gyu S HeoYongjian Liu
Aug 11, 2020·Current Cardiology Reports·Andrej ĆorovićJason M Tarkin
Jan 2, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Gurneet S SanghaAlisa M Clyne
Sep 10, 2020·Nuclear Medicine and Biology·Heinz H Coenen, Johannes Ermert
Mar 12, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Frank M Bengel
Oct 30, 2021·Molecular Medicine Reports·Yali ZhangEnqi Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Hannah P LuehmannYongjian Liu
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Yongjian LiuMichael J Welch
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Yongjian LiuMichael J Welch
© 2022 Meta ULC. All rights reserved