PET/CT imaging of renal cell carcinoma with (18)F-VM4-037: a phase II pilot study

Abdominal Radiology
Baris TurkbeyAdam R Metwalli

Abstract

Carbonic anhydrase IX (CA-IX) is a potential imaging biomarker of clear cell renal cell carcinoma (ccRCC). Here, we report the results of a phase II clinical trial of a small molecule radiotracer targeting CA-IX ((18)F-VM4-037) in ccRCC. Between October 2012 and May 2013, 11 patients with kidney masses underwent (18)F-VM4-037 PET/CT prior to surgery. Dynamic imaging was performed for the first 45 min post injection and whole-body imaging was obtained at 60 min post injection. Tumors were surgically excised or biopsied within 4 weeks of imaging. All patients tolerated the radiotracer well with no adverse events. Ten of the 11 patients had histologically confirmed malignancy. One patient had a Bosniak Type 3 cyst with no tumor found at surgery. Two patients had extrarenal disease and 9 had tumors only in the kidney. Primary ccRCC lesions were difficult to visualize on PET alone due to high uptake of the tracer in the adjacent normal kidney parenchyma, however when viewed in conjunction with CT, the tumors were easily localized. Metastatic lesions were clearly visible on PET. Mean SUV for primary kidney lesions was 2.55 in all patients; in patients with histologically confirmed ccRCC, the mean SUV was 3.16. The time-activity curve...Continue Reading

Associated Clinical Trials

Oct 23, 2012·Adam Metwalli, M.D., Adam Metwalli, M.D.

References

Apr 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E OosterwijkG J Fleuren
Jul 3, 2003·British Journal of Cancer·C P S Potter, A L Harris
Nov 25, 2003·The Journal of Urology·W Marston LinehanBerton Zbar
Dec 22, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William Y Kim, William G Kaelin
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradley C LeibovichEugene D Kwon
Feb 9, 2008·Cell Death and Differentiation·E B Rankin, A J Giaccia
May 9, 2008·International Journal of Cancer. Journal International Du Cancer·Jean-Jacques PatardAllan J Pantuck
Oct 17, 2008·Nature Reviews. Cancer·William G Kaelin
Mar 23, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Daniel A PrymaChaitanya R Divgi
May 7, 2011·Cellular Oncology (Dordrecht)·Michelle J NyhanSharon L McKenna
Dec 20, 2011·Histopathology·Daniel P DonatoDebra L Zynger
Apr 11, 2012·The Urologic Clinics of North America·Brian ShuchGennady Bratslavsky
Mar 5, 2013·European Urology·Constantijn H J MuselaersPeter F A Mulders
Dec 5, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ramez N Eskander, Krishnansu S Tewari
Apr 4, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Mohan DossJian Q Yu
Jun 24, 2015·PET Clinics·Kirsten Bouchelouche, Peter L Choyke

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Citations

May 20, 2016·Abdominal Radiology·Reza SirousAndrew D Smith
Apr 8, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Zhengxing ZhangKuo-Shyan Lin
Jan 4, 2018·Metabolites·Elisabetta IessiStefano Fais
Feb 13, 2019·Current Opinion in Oncology·Liza LindenbergKirsten Bouchelouche
Jun 5, 2016·Current Opinion in Urology·Katherine M Krajewski, Atul B Shinagare
Jan 11, 2018·Current Opinion in Urology·Alexa R MeyerMichael A Gorin
Oct 2, 2020·International Journal of Molecular Sciences·Jean CourcierAlexandre Ingels
Dec 12, 2020·European Journal of Medicinal Chemistry·Valeria BurianovaMikhail Krasavin
May 10, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Katarzyna StaszakKrzysztof Roszkowski
Jul 1, 2021·Nature Reviews. Nephrology·Barbara M KlinkhammerPeter Boor

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