PET/CT in the diagnosis and prognosis of osteosarcoma.

Frontiers in Bioscience (Landmark Edition)
Xiaojuan Zhang, Zhe Guan

Abstract

Osteosarcoma is an aggressive malignancy that usually occurs in children and young adults, and long-term survival is only about 20% in patients with metastasis or recurrent disease. Traditional non-invasive techniques, such as positron-emission tomography (PET) scanning, magnetic resonance imaging (MRI) or computed tomography (CT) scanning, may not identify single lesions in the early stage or accurately detect small lesions. A novel technique, positron emission tomography/computed tomography (PET/CT), which is widely used in clinical practice, shows more accuracy, sensitivity, and specificity in the diagnosis of osteosarcoma. PET/CT provides information not only for diagnosis of primary lesion and metastases, but also for histological response to neoadjuvant chemotherapy and prognosis. Here, we review the role of PET/CT in the diagnosis and prognosis of osteosarcoma.

Citations

Feb 8, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Katharina SeidensaalSemi B Harrabi
Aug 14, 2020·Experimental Biology and Medicine·Emel RothzergSulev Kõks
Oct 13, 2020·Journal of Cellular Physiology·Shenglong Li, Xiaohong Wang

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