PET/MRI Hybrid Systems

Seminars in Nuclear Medicine
Julia G MannheimJonathan A Disselhorst

Abstract

Over the last decade, the combination of PET and MRI in one system has proven to be highly successful in basic preclinical research, as well as in clinical research. Nowadays, PET/MRI systems are well established in preclinical imaging and are progressing into clinical applications to provide further insights into specific diseases, therapeutic assessments, and biological pathways. Certain challenges in terms of hardware had to be resolved concurrently with the development of new techniques to be able to reach the full potential of both combined techniques. This review provides an overview of these challenges and describes the opportunities that simultaneous PET/MRI systems can exploit in comparison with stand-alone or other combined hybrid systems. New approaches were developed for simultaneous PET/MRI systems to correct for attenuation of 511 keV photons because MRI does not provide direct information on gamma photon attenuation properties. Furthermore, new algorithms to correct for motion were developed, because MRI can accurately detect motion with high temporal resolution. The additional information gained by the MRI can be employed to correct for partial volume effects as well. The development of new detector designs in c...Continue Reading

Citations

Dec 7, 2018·Physics in Medicine and Biology·Aaron R SelfridgeMartin S Judenhofer
Apr 3, 2020·The British Journal of Radiology·Nicholas R EvansJames Hf Rudd
Jun 7, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kristina HerfertBernd J Pichler
Nov 14, 2019·Physics in Medicine and Biology·Qian YangJunwei Du
Feb 17, 2019·La Radiologia medica·Massimo SalvatoriOrazio Schillaci
Jun 27, 2020·Physics in Medicine and Biology·Willy GsellAntonio J Gonzalez
May 2, 2020·Physics in Medicine and Biology·Robert S Miyaoka, Adrienne L Lehnert
Aug 30, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jan GrimmBernd J Pichler

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