PET/SPECT: functional imaging beyond flow

Vision Research
A A Lammertsma

Abstract

In this review, first principles of positron emission tomography (PET) and single photon emission tomography (SPECT) are discussed together with the relative strengths and weaknesses of both techniques. With both modalities it is possible to image and, especially with PET, to measure regional tissue function, the particular function being interrogated depending on the actual tracer being used. In the second part, the use of PET for neuroactivation studies is presented, illustrated with some key examples from the literature using both perfusion and metabolism tracers. It is argued that the future of PET (and SPECT) neuroactivation studies lies in the use of ligands. Possible approaches for performing ligand activation studies are discussed.

References

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Citations

Jul 23, 2003·Current Opinion in Oncology·Noobar Israel-Mardirosian, Lee P Adler
May 23, 2006·Journal of Physiology, Paris·Andreas Otte, Ulrike Halsband
Jul 22, 2015·Clinics in Liver Disease·Raja G R Edula, Nikolaos T Pyrsopoulos
Aug 8, 2008·Critical Reviews in Toxicology·Olavi PelkonenArmel Stockis
Jan 1, 2005·Drug Discovery Today. Technologies·Eugenii A Rabiner
Dec 31, 2016·Experimental Neurobiology·Jooyeon Jamie ImSujung Yoon
Jul 3, 2019·Interdisciplinary Sciences, Computational Life Sciences·Delin LiuXin Cheng
Aug 31, 2016·World Journal of Hepatology·Fernando Mendes PaschoalEdson Bor-Seng-Shu
Feb 16, 2007·Physics in Medicine and Biology·Hugo W A M de JongAdriaan A Lammertsma
Sep 19, 2003·Journal of Child Neurology·Alexander H HoonLidia M Nagae-Poetscher

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