PETSTEP: Generation of synthetic PET lesions for fast evaluation of segmentation methods

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
Beatrice BerthonC Ross Schmidtlein

Abstract

This work describes PETSTEP (PET Simulator of Tracers via Emission Projection): a faster and more accessible alternative to Monte Carlo (MC) simulation generating realistic PET images, for studies assessing image features and segmentation techniques. PETSTEP was implemented within Matlab as open source software. It allows generating three-dimensional PET images from PET/CT data or synthetic CT and PET maps, with user-drawn lesions and user-set acquisition and reconstruction parameters. PETSTEP was used to reproduce images of the NEMA body phantom acquired on a GE Discovery 690 PET/CT scanner, and simulated with MC for the GE Discovery LS scanner, and to generate realistic Head and Neck scans. Finally the sensitivity (S) and Positive Predictive Value (PPV) of three automatic segmentation methods were compared when applied to the scanner-acquired and PETSTEP-simulated NEMA images. PETSTEP produced 3D phantom and clinical images within 4 and 6 min respectively on a single core 2.7 GHz computer. PETSTEP images of the NEMA phantom had mean intensities within 2% of the scanner-acquired image for both background and largest insert, and 16% larger background Full Width at Half Maximum. Similar results were obtained when comparing PETST...Continue Reading

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Citations

Oct 6, 2018·Medical Physics·Seyedehsamaneh ShojaeilangariMohammad Reza Ay
Sep 19, 2018·EJNMMI Physics·Elisabeth PfaehlerRonald Boellaard
Sep 1, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Angel Torrado-CarvajalCiprian Catana
Jul 19, 2021·Computer Methods and Programs in Biomedicine·Yanchao HuangQianjin Feng
Aug 6, 2021·Radiology. Artificial Intelligence·Nicholas JosselynWalter R Witschey

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Methods Mentioned

BETA
IEC

Software Mentioned

PET
SPSS
PETSTEP ( PET Simulator of Tracers via Emission Projection )
PETSTEP GATE
- AS set
CERR
Matlab
STIR
OSEM
PETSTEP

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