PMID: 428921Jan 1, 1979Paper

Peutz--Jeghers syndrome with pseudoinvasion of hamartomatous polyps and multiple epithelial neoplasms

Histopathology
J S Bolwell, P D James

Abstract

The risk of malignant change developing in the hamartomatous polyps in Peutz-Jeghers syndrome is widely held to be negligible. However an association with tumours of the upper gastro-intestinal tract, ovary and other diverse multiple neoplasms is now recognized. Previously reported cases of malignant change in Peutz--Jeghers polyps may represent 'pseudoinvasion' and we report such a case. This was associated with carcinomas of the bile ducts, left tonsil and a papillary adenoma of the pancreatic duct. It lends further support to the view that there may be a genetic predisposition to the development of neoplasms in this condition. Pathologists and clinicians must be aware of this entity of 'pseudoinvasion' in order to avoid unnecessarily radical surgery in Peutz-Jeghers syndrome.

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Citations

Aug 1, 1987·Digestive Diseases and Sciences·K WadaK Wada
Oct 1, 1993·Diseases of the Colon and Rectum·K HizawaM Fujishima
Jan 13, 2000·The American Journal of Surgical Pathology·V C PetersenN A Shepherd
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May 22, 2001·Perceptual and Motor Skills·A DeflandreG Falgairette
Jul 1, 1984·Scottish Medical Journal·J Kyle

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