PMID: 9425153Feb 14, 1998Paper

Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery

The Journal of Cell Biology
B HuhseW H Kunau

Abstract

The Saccharomyces cerevisiae pex17-1 mutant was isolated from a screen to identify mutants defective in peroxisome biogenesis. pex17-1 and pex17 null mutants fail to import matrix proteins into peroxisomes via both PTS1- and PTS2-dependent pathways. The PEX17 gene (formerly PAS9; Albertini, M., P. Rehling, R. Erdmann, W. Girzalsky, J.A.K.W. Kiel, M. Veenhuis, and W.-H Kunau. 1997. Cell. 89:83-92) encodes a polypeptide of 199 amino acids with one predicted membrane spanning region and two putative coiled-coil structures. However, localization studies demonstrate that Pex17p is a peripheral membrane protein located at the surface of peroxisomes. Particulate structures containing the peroxisomal integral membrane proteins Pex3p and Pex11p are evident in pex17 mutant cells, indicating the existence of peroxisomal remnants ("ghosts"). This finding suggests that pex17 null mutant cells are not impaired in peroxisomal membrane biogenesis. Two-hybrid studies showed that Pex17p directly binds to Pex14p, the recently proposed point of convergence for the two peroxisomal targeting signal (PTS)-dependent import pathways, and indirectly to Pex5p, the PTS1 receptor. The latter interaction requires Pex14p, indicating the potential of these th...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 15, 1992·The Biochemical Journal·M J de Hoop, G Ab
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·P M Chevray, D Nathans
Nov 1, 1990·The Journal of Cell Biology·M P Rout, J V Kilmartin
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R ErdmannW H Kunau
May 1, 1989·The Journal of Cell Biology·S J GouldS Subramani
Jan 30, 1986·Biochimica Et Biophysica Acta·J K Mohana Rao, P Argos
Jun 1, 1987·Yeast·M VeenhuisW Harder
May 28, 1985·Biochimica Et Biophysica Acta·P KleinC DeLisi
Jan 1, 1985·Annual Review of Cell Biology·P B Lazarow, Y Fujiki
Oct 15, 1984·Journal of Molecular Biology·D EisenbergR Wall
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Nov 17, 1995·Cell·R A Rachubinski, S Subramani
Apr 1, 1995·The Journal of Cell Biology·P A MarshallJ M Goodman
May 1, 1994·The Journal of Cell Biology·A MotleyH Tabak
Jan 1, 1993·Annual Review of Cell Biology·S Subramani
Feb 1, 1993·The Journal of Cell Biology·F KraglerA Hartig
Jan 1, 1996·Methods in Enzymology·A Lupas
Sep 1, 1996·European Journal of Biochemistry·F Blobel, R Erdmann
Feb 1, 1996·Trends in Biochemical Sciences·J A McNew, J M Goodman
Oct 1, 1996·The Journal of Cell Biology·B DistelM Veenhuis
Oct 1, 1996·The Journal of Cell Biology·R Erdmann, G Blobel
Dec 20, 1996·The Journal of Biological Chemistry·S Subramani
Oct 29, 1996·Biochimica Et Biophysica Acta·Y Elgersma, H F Tabak
Dec 27, 1996·Annals of the New York Academy of Sciences·P RehlingW H Kunau
Apr 1, 1997·Nature Genetics·S Subramani
Aug 22, 2007·Trends in Cell Biology·R ErdmannW H Kunau

❮ Previous
Next ❯

Citations

May 30, 2001·Molecular and Biochemical Parasitology·M ParsonsP Kessler
Mar 6, 1999·Current Opinion in Microbiology·W H Kunau
May 2, 2001·Nature Reviews. Molecular Cell Biology·V I Titorenko, R A Rachubinski
Jun 3, 2000·Nature Biotechnology·M Y Galperin, E V Koonin
Apr 30, 2003·Nature Cell Biology·Naomi MatsumotoYukio Fujiki
Aug 17, 2005·Nature Reviews. Molecular Cell Biology·Ralf Erdmann, Wolfgang Schliebs
Jul 3, 2009·Molecular Biology of the Cell·Changle MaSuresh Subramani
Nov 1, 2001·Annual Review of Cell and Developmental Biology·P E Purdue, P B Lazarow
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Sabine WellerDavid Valle
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·M FransenS Subramani
Sep 18, 2012·Cellular and Molecular Life Sciences : CMLS·Harald W PlattaRalf Erdmann
Jul 29, 1998·The Journal of Cell Biology·E H HettemaI Braakman
Jul 18, 2001·FEBS Letters·C Holroyd, R Erdmann
Aug 24, 2010·European Journal of Cell Biology·David ManagadzeHanspeter Rottensteiner
Jul 27, 2010·European Journal of Cell Biology·Markus DeckersRalf Erdmann
Sep 11, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Marco Fidaleo
Oct 27, 2015·Biochimica Et Biophysica Acta·Michael MeineckeRichard Wagner
May 12, 2005·The FEBS Journal·Ines Heiland, Ralf Erdmann
Feb 1, 2005·Clinical Genetics·R J A Wanders, H R Waterham
May 13, 2003·Microscopy Research and Technique·Marten VeenhuisIda J Van Der Klei
Feb 3, 2004·Journal of Cellular and Molecular Medicine·Laura-Anne Brown, Alison Baker
Oct 10, 2015·Biochimica Et Biophysica Acta·Leonidas EmmanouilidisMichael Sattler
Jan 13, 2006·Journal of Molecular Biology·Andreia F CarvalhoJorge E Azevedo
Sep 15, 2015·Biochimica Et Biophysica Acta·Harald W PlattaChristian Eggeling
Aug 12, 1999·American Journal of Human Genetics·Y LiuS J Gould
Aug 21, 2013·Biochimie·Tânia FranciscoCláudia P Grou
May 24, 2012·Biochimica Et Biophysica Acta·Shirisha NagotuHarald W Platta

❮ Previous
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