Peyer's patch innate lymphoid cells regulate commensal bacteria expansion

Immunology Letters
Masaaki HashiguchiTetsuji Kobata

Abstract

Anatomical containment of commensal bacteria in the intestinal mucosa is promoted by innate lymphoid cells (ILCs). However, the mechanism by which ILCs regulate bacterial localization to specific regions remains unknown. Here we show that Peyer's patch (PP) ILCs robustly produce IL-22 and IFN-γ in the absence of exogenous stimuli. Antibiotic treatment of mice decreased both IL-22+ and IFN-γ+ cells in PPs. Blockade of both IL-2 and IL-23 signaling in vitro lowered IL-22 and IFN-γ production. PP ILCs induced mRNA expression of the antibacterial proteins RegIIIβ and RegIIIγ in intestinal epithelial cells. Furthermore, in vivo depletion of ILCs rather than T cells altered bacterial composition and allowed bacterial proliferation in PPs. Collectively, our results show that ILCs regulate the expansion of commensal bacteria in PPs.

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Citations

May 15, 2015·Nature Reviews. Gastroenterology & Hepatology·Rimma GoldbergNick Powell
Jun 22, 2018·Journal of Dental Research·J L BrownS Culshaw
Apr 27, 2019·Future Microbiology·Amadou TogoMatthieu Million
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Jun 4, 2018·Brain : a Journal of Neurology·Carlos R Camara-LemarroyV Wee Yong
Nov 16, 2017·Molecular Medicine Reports·Jirakrit Saetang, Surasak Sangkhathat
Jun 15, 2019·Current Rheumatology Reports·Daniele MauroFrancesco Ciccia
Nov 16, 2018·Frontiers in Physiology·Elizabeth A KennedyMegan T Baldridge
Nov 13, 2018·Frontiers in Immunology·Derek MillerNardhy Gomez-Lopez

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