PMID: 9177215Jun 10, 1997Paper

Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

Proceedings of the National Academy of Sciences of the United States of America
M PasparakisG Kollias

Abstract

Targeted inactivation of genes in the tumor necrosis factor (TNF)/lymphotoxin (LT) ligand and receptor system has recently revealed essential roles for these molecules in lymphoid tissue development and organization. Lymphotoxin-alphabeta (LTalphabeta)/lymphotoxin-beta receptor (LTbeta-R) signaling is critical for the organogenesis of lymph nodes and Peyer's patches and for the structural compartmentalization of the splenic white pulp into distinct B and T cell areas and marginal zones. Moreover, an essential role has been demonstrated for TNF/p55 tumor necrosis factor receptor (p55TNF-R) signaling in the formation of splenic B lymphocyte follicles, follicular dendritic cell networks, and germinal centers. In contrast to a previously described essential role for the p55TNF-R in Peyer's patch organogenesis, we show in this report that Peyer's patches are present in both TNF and p55TNF-R knockout mice, demonstrating that these molecules are not essential for the organogenesis of this lymphoid organ. Furthermore, we show that in the absence of TNF/p55TNF-R signaling, lymphocytes segregate normally into T and B cell areas and a normal content and localization of dendritic cells is observed in both lymph nodes and Peyer's patches. H...Continue Reading

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Citations

Mar 4, 1998·European Journal of Immunology·M GrellP Scheurich
Mar 4, 1999·European Journal of Immunology·H P EugsterA Fontana
Apr 12, 2001·European Journal of Immunology·T W SpahnH L Weiner
Sep 28, 2000·Cellular Immunology·H HussonA S Freedman
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Mar 29, 2008·Annual Review of Immunology·Troy D RandallJavier Rangel-Moreno

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