Peyronie's disease is associated with Paget's disease of bone

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
K LylesC C Carson

Abstract

Peyronie's disease is an idiopathic disorder in which an inflammatory fibrosis occurs in the tunica albuginea of the corpora cavernosa which causes the erect penis to become deformed. Peyronie's disease has a prevalence of 1% in men over age 50 years. Paget's disease of bone is a chronic skeletal disease with areas of increased bone turnover leading to pain, deformity, and in some cases arthritis. Because of a high rate of Peyronie's disease in subjects in a Paget's disease industry-sponsored drug trial, we asked whether there was an association between Peyronie's disease and Paget's disease of bone. We evaluated 61 men with Paget's disease attending our clinic for metabolic bone disease in a tertiary referral hospital, reviewed hospital records of all men discharged from our three hospitals with the diagnosis of Peyronie's disease, and mailed a validated questionnaire about shape of the erect penis to 1500 male members of the Paget Foundation. In the clinic population of men with Paget's disease of bone, 51 of 61 (83.6%) reported having normal erections; 10 patients (16.4%) were impotent. Sixteen of the 51 men (31.4%) had developed a bend or deformity in their erect penis which was confirmed by a urologist's examination to be ...Continue Reading

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Citations

Jul 25, 2008·International Journal of Impotence Research·J F SmithT F Lue
Apr 23, 2004·Expert Opinion on Pharmacotherapy·Zafar MaanHitendra R H Patel
Apr 1, 2009·Therapeutic Advances in Musculoskeletal Disease·Joseph L Shaker
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Dec 6, 2001·Current Opinion in Urology·G H Lischer, A Nehra
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Mar 27, 2021·Current Allergy and Asthma Reports·Emily M RabjohnsTeresa K Tarrant
Jun 14, 2001·The Urologic Clinics of North America·S S Gholami, T F Lue

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