Mar 21, 2000

PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities

The Journal of Antibiotics
H NoseT Shomura

Abstract

Two novel antifungal antibiotics, PF1163A and B, were isolated from the fermentation broth of Penicillium sp. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies. PF1163A and B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotoxic activity against mammalian cells. These compounds inhibited the ergosterol biosynthesis in Candida albicans.

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Mentioned in this Paper

Candida albicans
Pathogenic Organism
Antibiotics, Antifungal
Chromatography
PF 1163A
PF 1163B
Lumisterol
Sephadex LH 20
Candida albicans extract
Silica Measurement

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