PFAS exposure and overweight/obesity among children in a nationally representative sample.

Chemosphere
Sarah Dee GeigerZhengmin Qian

Abstract

Perfluoroalkyl substances (PFASs) are a class of manmade chemicals commonly used in consumer product manufacturing. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are two of the most highly studied PFASs. Both are present in the blood of the most Americans. PFASs are associated with intermediate cardiovascular disease (CVD) outcomes, but their relationship with obesity, a risk factor for intermediate and advanced CVD, remains largely unconfirmed. In this context, we aimed to explore the relationship between PFASs and both overweight/obesity and abdominal obesity among children. We examine associations between PFOA and PFOS levels, and Body Mass Index (BMI) and waist circumference (WC) in a representative sample (N = 2473) of US children, aged 12-18 years from the Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey 1999-2012. Overweight/obesity is defined as age-, sex-specific BMI z-score ≥ 85th percentile; abdominal obesity is defined as age-, sex-specific waist circumference ≥90th percentile. Associations between PFASs and anthropometric outcomes show a dose-response relationship overall. For overweight/obese BMI z-score, findings indicate OR = 1.42 and 95% CI: 0.85...Continue Reading

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Citations

Feb 19, 2021·JMIR MHealth and UHealth·Carmen BenavidesNatalia Arias
May 31, 2021·Environmental Pollution·Krystyna MakowskaSlawomir Gonkowski
May 27, 2021·Reviews on Environmental Health·Maryam Zare JeddiCristina Canova
Jun 3, 2021·International Journal of Molecular Sciences·Raquel CanoValmore Bermúdez
Jul 1, 2021·Environmental Health : a Global Access Science Source·Mathilde Lolk ThomsenKatharina M Main
Aug 8, 2021·International Journal of Environmental Research and Public Health·Taemin HaKaren Gaudreault
Aug 28, 2021·International Journal of Environmental Research and Public Health·Siti Suhana Abdullah SoheimiSiti Hamimah Sheikh Abdul Kadir

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