PFC mTOR signaling as a biological signature for cognitive deficits in bipolar disorder without psychosis.

Cell Reports Medicine
Jelena Radulovic, Vilma Gabbay

Abstract

Vanderplow et al.1 report decreased PFC Akt-mTOR signaling in males with bipolar disorder (BD) without psychosis compared with those with psychosis, possibly related to cognitive deficits. Understanding how cognition differs between these BD subtypes clinically and biologically remains a challenge.

References

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Oct 30, 2013·Nature Neuroscience·Mauro Costa-Mattioli, Lisa M Monteggia
Nov 28, 2015·British Journal of Clinical Pharmacology·Zuleide M IgnácioJoão Quevedo
May 23, 2017·Psychological Bulletin·Dennis Norris
Feb 25, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chadi G AbdallahJohn H Krystal

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