PfEMP1: an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum

The International Journal of Biochemistry & Cell Biology
Noa D Pasternak, Ron Dzikowski

Abstract

The deadliest form of human malaria is caused by the protozoan parasite Plasmodium falciparum affecting millions worldwide every year. P. falciparum virulence is attributed to its ability to evade the human immune system by modifying infected host red blood cells to adhere to the vascular endothelium and to undergo antigenic variation. The main antigenic ligands responsible for both cytoadherence and antigenic variation are members of the P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1) family. These polymorphic proteins are encoded by a multi-copy gene family called var. Each individual parasite expresses a single var gene at a time, maintaining the remaining approximately 60 var genes found in its genome in a transcriptionally silent state. As the antibody response against the single expressed PfEMP1 develops, small sub-populations of parasites switch expression to alternative forms of PfEMP1 and re-establish the infection. Therefore, PfEMP1 is considered a key player in the pathogenicity of P. falciparum.

References

Jun 24, 1994·Science·L H MillerG Milon
Jun 1, 2005·Journal of Cell Science·Paul HorrocksChris I Newbold
Jul 4, 2006·Current Opinion in Microbiology·Susan M Kraemer, Joseph D Smith
Jan 26, 2007·The Lancet Infectious Diseases·Stephen J RogersonDiane W Taylor
Jul 10, 2007·Molecular Microbiology·Jacqui MontgomeryAlister Craig
Sep 13, 2008·Annual Review of Microbiology·Artur ScherfLoïc Riviere

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Citations

Apr 27, 2010·Medical Microbiology and Immunology·Andrea KuehnGabriele Pradel
Feb 9, 2011·Immunology and Cell Biology·Alessandra Mortellaro, Paola Ricciardi-Castagnoli
Feb 8, 2013·Nature Medicine·Eleanor M Riley, V Ann Stewart
Jul 8, 2011·Journal of the Royal Society, Interface·Maite SeverinsHans Heesterbeek
Jan 8, 2010·Genome Research·Nadia PontsKarine G Le Roch
Aug 30, 2011·Malaria Journal·Matthew C RileyChristian F Ockenhouse
Apr 14, 2011·Evolutionary Bioinformatics Online·Atish KathpalSwati Patankar
Nov 6, 2012·The Veterinary Quarterly·Maite Severins
Feb 14, 2013·Biochemical and Biophysical Research Communications·Mamoru NiikuraFumie Kobayashi
Sep 12, 2012·Infectious Disease Clinics of North America·Wilson W ChanAndrea K Boggild
Dec 6, 2011·Pharmacology & Therapeutics·Nathalie GeurtsPhilippe E Van den Steen
Jul 6, 2010·Trends in Parasitology·Sejal GohilBrian M Cooke
Oct 9, 2015·Journal of the History of the Neurosciences·F J Rodriguez Porcel, H S Schutta
Jun 20, 2014·Current Opinion in Microbiology·Till S VossRichárd Bártfai
Aug 9, 2015·Interdisciplinary Sciences, Computational Life Sciences·Manoj Kumar Yadav, D Swati
Jul 22, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lauren M ChildsSarah Cobey
Dec 6, 2011·International Journal for Parasitology·Lucas M FerreriTerry F McElwain
Aug 15, 2014·Frontiers in Cellular and Infection Microbiology·Janet Storm, Alister G Craig
Dec 4, 2014·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Ankit GuptaSanjay A Desai
Jun 6, 2009·Current Opinion in Immunology·Sofia Casares, Thomas L Richie
Sep 9, 2011·Memórias do Instituto Oswaldo Cruz·Fabio T M CostaHernando del Portillo
May 17, 2017·The Korean Journal of Parasitology·Ui-Han SonYoun-Kyoung Goo
Aug 8, 2014·Memórias do Instituto Oswaldo Cruz·Alessandra Sampaio Bassi FratusGerhard Wunderlich
Nov 5, 2014·Molecular & Cellular Proteomics : MCP·Josh RicherPhillip Stafford
Nov 10, 2011·Nature Communications·Tarun Kumar BhattAmit Sharma
Aug 31, 2018·European Journal of Immunology·Christoph Konradt, Christopher A Hunter
Mar 20, 2019·Scientific Reports·Jan-Gero SchloetelMichał Pasternak
Jan 6, 2019·EMBO Molecular Medicine·Janet StormAlister G Craig

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