Nov 7, 2019

PFM-Like Enzymes Are a Novel Family of Subclass B2 Metallo-β-Lactamases from Pseudomonas synxantha Belonging to the Pseudomonas fluorescens Complex

Antimicrobial Agents and Chemotherapy
Laurent PoirelPatrice Nordmann

Abstract

A carbapenem-resistant Pseudomonas synxantha isolate recovered from chicken meat produced the novel carbapenemase PFM-1. That subclass B2 metallo-β-lactamase shared 71% amino acid identity with β-lactamase Sfh-1 from Serratia fonticola The blaPFM-1 gene was chromosomally located and likely acquired. Variants of PFM-1 sharing 90% to 92% amino acid identity were identified in bacterial species belonging to the Pseudomonas fluorescens complex, including Pseudomonas libanensis (PFM-2) and Pseudomonas fluorescens (PFM-3), highlighting that these species constitute reservoirs of PFM-like encoding genes.

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  • Citations1

Citations

Mentioned in this Paper

Genes
PFM3
ALX4 gene
Beta-Lactamase
Pseudomonas libanensis
Pharmacologic Substance
PRDM4 protein, human
Isolate - Microorganism
Pseudomonas synxantha
Location

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