PFO closure for secondary stroke prevention: is the discussion closed?

Journal of Thrombosis and Thrombolysis
Joseph J ShatzelThomas G DeLoughery

Abstract

Three previous reports of PFO closure for secondary stroke prevention failed to find any significant benefit. Recently however, three conflicting reports were published suggesting a benefit in select patients. Although we are enthusiastic for PFO closure in appropriate patients, caution is warranted in the extrapolation of this data and the application of this intervention to broader patient groups. Only small minorities of stroke patients are likely to benefit from PFO closure, the intervention has a notable complication rate, and it has not been compared against modern anticoagulation options. Clinicians should consider all of these points as discussions around PFO closure are likely to become more and more common going forward.

References

Feb 12, 2011·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN AVERROES Steering Committee and Investigators
Mar 16, 2012·The New England Journal of Medicine·Anthony J FurlanUNKNOWN CLOSURE I Investigators
Mar 22, 2013·The New England Journal of Medicine·Bernhard MeierUNKNOWN PC Trial Investigators
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Sep 14, 2017·The New England Journal of Medicine·Lars SøndergaardUNKNOWN Gore REDUCE Clinical Study Investigators
Sep 14, 2017·The New England Journal of Medicine·Jeffrey L SaverUNKNOWN RESPECT Investigators
Sep 14, 2017·The New England Journal of Medicine·Jean-Louis MasUNKNOWN CLOSE Investigators

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Citations

Feb 28, 2021·Journal of Thrombosis and Thrombolysis·Constantina AggeliKostas Tsioufis
Jun 24, 2021·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Radomir NyklMilos Taborsky

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