PFstats: A Network-Based Open Tool for Protein Family Analysis

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
Néli J Fonseca-JúniorLucas Bleicher

Abstract

PFstats is a software developed for the extraction of useful information from protein multiple sequence alignments. By analyzing positional conservation and residue coevolution networks, the software allows the identification of structurally and functionally important residue groups and the discovery of probable functional subclasses. Furthermore, it contains tools for the identification of the possible biological significance of these findings. PFstats contains methods for maximizing the significance of alignments through filtering and weighting, residue conservation and coevolution analysis, automatic UniprotKb queries for residue-position annotation and many possible data visualization methods.

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Citations

Jul 3, 2020·BMC Molecular and Cell Biology·Diego MarianoRaquel Cardoso de Melo-Minardi
Jun 3, 2020·Nature Communications·Anna Barwinska-SendraKevin J Waldron
Jan 3, 2020·Journal of Chemical Information and Modeling·Marcelo Querino Lima AfonsoLucas Bleicher

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Software Mentioned

Linux
QcustomPlot
3Dmol
MSAViewer
OTCase
PFstats
Windows
GPLV3
OpenMP
CS

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