Pga13 in Candida albicans is localized in the cell wall and influences cell surface properties, morphogenesis and virulence

Fungal Genetics and Biology : FG & B
Samuel GelisEulogio Valentín

Abstract

The fungal cell wall is an essential organelle required for maintaining cell integrity and also plays an important role in the primary interactions between pathogenic fungi and their hosts. PGA13 encodes a GPI protein in the human pathogen Candida albicans, which is highly up-regulated during cell wall regeneration in protoplasts. The Pga13 protein contains a unique tandem repeat, which is present five times and is characterized by conserved spacing between the four cysteine residues. Furthermore, the mature protein contains 38% serine and threonine residues, and therefore probably is a highly glycosylated cell wall protein. Consistent with this, a chimeric Pga13-V5 protein could be localized to the cell wall, but only after deglycosylation was performed. Disruption of PGA13 led to increased sensitivity to Congo red, Calcofluor white, and zymolyase, and to a diminished ability of protoplasts to recover their cell wall. In addition, pga13Δ mutants exhibited delayed filamentation, a higher surface hydrophobicity, and increased adherence and flocculation (cell-cell interactions). Furthermore, transcript profiling showed that expression of four members of the ALS family (adhesin-encoding genes) is up-regulated in the pga13Δ null mu...Continue Reading

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Citations

Feb 12, 2013·Eukaryotic Cell·Piet W J de GrootNeeraj Chauhan
Jun 5, 2013·International Journal of Medical Microbiology : IJMM·Qilin YuMingchun Li
Sep 1, 2015·PLoS Neglected Tropical Diseases·Clarissa Xavier Resende ValimMaria Célia Jamur
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Oct 20, 2017·The International Journal of Artificial Organs·Marcelo E Fernández-RiveroEmilia Cantón
Sep 1, 2019·International Journal of Medical Microbiology : IJMM·Yanjun SongHong Zhang
Nov 11, 2020·Antimicrobial Agents and Chemotherapy·Kang XiongYang Lu
Nov 20, 2021·International Journal of Antimicrobial Agents·Chibuike IbeOmran Alamir

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