PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy.

The Journal of Biological Chemistry
Shiqin XiongR W Alexander

Abstract

Angiotensin II (Ang II) is a pleuripotential hormone that is important in the pathophysiology of multiple conditions including aging, cardiovascular and renal diseases, and insulin resistance. Reactive oxygen species (ROS) are important mediators of Ang II-induced signaling generally and have a well defined role in vascular hypertrophy, which is inhibited by overexpression of catalase, inferring a specific role of H(2)O(2). The molecular mechanisms are understood incompletely. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) is a key regulator of energy metabolism and ROS-scavenging enzymes including catalase. We show that Ang II stimulates Akt-dependent PGC-1 alpha serine 570 phosphorylation, which is required for the binding of the histone acetyltransferase GCN5 (general control nonderepressible 5) to PGC-1 alpha and for its lysine acetylation. These sequential post-translational modifications suppress PGC-1 alpha activity and prevent its binding to the catalase promoter through the forkhead box O1 transcription factor, thus decreasing catalase expression. We demonstrate that overexpression of the phosphorylation-defective mutant PGC-1 alpha (S570A) prevents An...Continue Reading

References

Jan 1, 1997·Hypertension·K K GriendlingR W Alexander
Feb 5, 2002·American Journal of Hypertension·Carlos M Ferrario
Sep 7, 2002·Circulation Research·Puvi N SeshiahKathy K Griendling
Sep 20, 2002·Nature·Geert J P L KopsBoudewijn M T Burgering
May 20, 2003·Nature·Pere PuigserverBruce M Spiegelman
Jul 16, 2003·The Journal of Biological Chemistry·Petra RocicKathy K Griendling
Apr 2, 2004·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·William Soo HooJeff Hall
Apr 16, 2004·American Journal of Physiology. Cell Physiology·Yoshihiro TaniyamaKathy K Griendling
Feb 3, 2005·Free Radical Biology & Medicine·Marc-André LaplanteJacques de Champlain
Feb 18, 2005·The Journal of Biological Chemistry·Shino NemotoToren Finkel
Mar 23, 2005·The Journal of Biological Chemistry·Carsten SkurkKenneth Walsh
May 26, 2005·Cardiovascular Research·Inmaculada ValleMaría Monsalve
Aug 2, 2005·Cell Metabolism·Jiandie LinBruce M Spiegelman
Aug 27, 2005·Cell·Christoph HandschinBruce M Spiegelman
Oct 18, 2005·Nature Reviews. Molecular Cell Biology·Toren Finkel
Mar 3, 2006·The Journal of Clinical Investigation·Brian N Finck, Daniel P Kelly
Jun 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zoltan AranyBruce M Spiegelman
Dec 23, 2006·Journal of Cellular Physiology·Balachandar VenkatesanGoutam Ghosh Choudhury
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sibylle JägerBruce M Spiegelman
Sep 18, 2007·Antioxidants & Redox Signaling·Kristina LeunerWalter E Müller
Feb 20, 2008·Experimental Cell Research·Teng Lu, Toren Finkel
Sep 6, 2008·The Journal of Biological Chemistry·Wei-Qi TanPei-Feng Li
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Narayana AnilkumarAjay M Shah

❮ Previous
Next ❯

Citations

Dec 15, 2010·Biochemistry·Yaroslava A Bulynko, Bert W O'Malley
Oct 5, 2010·Circulation Research·Glenn C RoweZolt Arany
Sep 5, 2012·The Journal of Clinical Investigation·Aruna KodeStavroula Kousteni
Jun 27, 2014·Cardiovascular Research·Osama Abo AlrobGary D Lopaschuk
Jul 16, 2011·Expert Opinion on Therapeutic Patents·Simone CarradoriAntonello Mai
Dec 17, 2014·Frontiers in Physiology·Ramya VajapeyPeter Abadir
Jun 7, 2018·Physiological Reviews·Steven J ForresterSatoru Eguchi
Jun 18, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew O KadlecDavid D Gutterman
Feb 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Shiqin XiongR Wayne Alexander
Jul 18, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Su-Bin KimKwang Seok Kim
Jan 16, 2020·Biomolecules·Petr JežekLydie Plecitá-Hlavatá
Jan 8, 2015·Journal of Exercise Nutrition & Biochemistry·Dae Ryoung ParkChang Keun Kim
May 2, 2018·International Journal of Molecular Sciences·Gloria Salazar
Jul 25, 2018·Frontiers in Endocrinology·Chien-Yu ChenBangyan L Stiles
Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Sergio Rius-PérezSalvador Pérez
Dec 15, 2010·The Journal of Biological Chemistry·Shiqin XiongR Wayne Alexander
Mar 21, 2020·Frontiers in Cardiovascular Medicine·Shafeeq A MohammedSarah Costantino
Dec 2, 2020·International Journal of Molecular Sciences·Jin Seong HyeonGeum-Sook Hwang
May 31, 2020·Mechanisms of Ageing and Development·Maurizio ForteSperanza Rubattu
Aug 23, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Beste Mutlu, Pere Puigserver
Oct 30, 2020·Frontiers in Neuroscience·Caglar CosardereliogluPeter M Abadir
Feb 5, 2021·Circulation Research·Ioannis D KyriazisKonstantinos Drosatos
Apr 3, 2021·Molecular and Cellular Endocrinology·Elena Cantero-NavarroAlberto Ortiz
Jul 6, 2021·Frontiers in Cardiovascular Medicine·Hong-Jin ChenPing-Jin Gao
Jul 13, 2021·Aging Medicine·Shan WangYongjun Mao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.