PGC-1α determines light damage susceptibility of the murine retina.

PloS One
Anna EggerC Handschin

Abstract

The peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) proteins are key regulators of cellular bioenergetics and are accordingly expressed in tissues with a high energetic demand. For example, PGC-1α and PGC-1β control organ function of brown adipose tissue, heart, brain, liver and skeletal muscle. Surprisingly, despite their prominent role in the control of mitochondrial biogenesis and oxidative metabolism, expression and function of the PGC-1 coactivators in the retina, an organ with one of the highest energy demands per tissue weight, are completely unknown. Moreover, the molecular mechanisms that coordinate energy production with repair processes in the damaged retina remain enigmatic. In the present study, we thus investigated the expression and function of the PGC-1 coactivators in the healthy and the damaged retina. We show that PGC-1α and PGC-1β are found at high levels in different structures of the mouse retina, most prominently in the photoreceptors. Furthermore, PGC-1α knockout mice suffer from a striking deterioration in retinal morphology and function upon detrimental light exposure. Gene expression studies revealed dysregulation of all major pathways involved in retinal damage and apoptosis, repai...Continue Reading

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Citations

Nov 22, 2013·Seminars in Immunopathology·Petra S Eisele, Christoph Handschin
Jun 22, 2018·Disease Models & Mechanisms·Meng ZhangNady Golestaneh
May 19, 2019·Life Science Alliance·Mariana Aparecida Brunini RosalesMagali Saint-Geniez
Feb 14, 2020·Scientific Reports·Meng ZhangNady Golestaneh
May 20, 2018·Cellular and Molecular Life Sciences : CMLS·Juha M T HyttinenJanusz Błasiak
Feb 27, 2020·International Journal of Molecular Sciences·Zhongjie FuLois E H Smith
Dec 14, 2018·Oxidative Medicine and Cellular Longevity·Sangeeta SatishMagali Saint-Geniez
Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Parameswaran G SreekumarRam Kannan
Dec 4, 2020·International Journal of Molecular Sciences·Janusz BlasiakKai Kaarniranta
Apr 17, 2020·Progress in Retinal and Eye Research·Kai KaarnirantaDeborah Ferrington
Nov 13, 2012·The American Journal of Pathology·Magali Saint-GeniezZoltan Arany

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Methods Mentioned

BETA
PCR
laser capture microdissection
protein folding
ELISA
gene knockout
fluorescence microscopy
Chip

Software Mentioned

PARTEK
Bioconductor

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