PMID: 3480891Sep 1, 1987

PGD2 induces pulmonary hyperresponsiveness to acetylcholine in vivo in the guinea-pig

Journal of Autonomic Pharmacology
G BrunelliF Berti


1 A threshold dose of Prostaglandin D2 (PGD2) (0.5 microgram/kg i.v.), which did not modify the basal values of airway resistance, potentiated the acetylcholine induced bronchospasm in anaesthetized guinea-pigs. 2 beta-adrenoreceptors blockade induced by propranolol enhanced the positive interaction between PGD2 and acetylcholine in the pulmonary dynamics. 3 Active sensitization of guinea-pigs by ovalbumin increased the pulmonary PGD2-acetylcholine interaction and the phenomenon was sustained during the time. 4 The inability of PGD2 to potentiate histamine-induced bronchoconstriction suggests a specificity for the interaction.


Jul 1, 1979·British Journal of Pharmacology·J Maclagan, U M Ney
Dec 1, 1986·Pharmacological Research Communications·A HernandezC Omini
Sep 1, 1986·Journal of Autonomic Pharmacology·C OminiF Berti
Aug 1, 1983·British Journal of Pharmacology·U M Ney
Jun 1, 1983·Prostaglandins, Leukotrienes, and Medicine·B R Creese, M K Bach
Sep 11, 1981·European Journal of Pharmacology·B B Vargaftig, J Lefort


Feb 28, 1989·European Journal of Pharmacology·L DaffonchioB J Whittle
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·B HalimF Camu

Related Concepts

Acetylcholine Sulfate (1: 1)
Airway Resistance
Bronchial Spasm
Drug Augmentation
Cavia porcellus
Prostaglandins D
Respiratory Hypersensitivity

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